Sensitization to dust mite defines different phenotypes of asthma: A multicenter study

Giuliana Ferrante, Gianluca Scaccianoce, Gianfranco Rizzo, Paolo Colombo, Fabio Cibella, Giuseppina Cuttitta, Gaspare Drago, Christopher Zammit, David Bilocca, Silvia Ruggieri, Valeria Longo, Martin Balzan, Stephen Montefort, Giovanni Viegi

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Background: Indoor allergens are risk factors for asthma: Thus, the characterization of indoor air quality is important for studying environment-health relationships in children. In particular, Dermatophagoides pteronyssinus is the dominant allergen for asthma. We cross-sectionally investigated the relationships among respiratory symptoms and function, airway inflammation, allergen sensitization, and indoor allergen concentration. Methods: One hundred and thirty-two children aging 10-14 years and living in a Southern Mediterranean area were evaluated by parental questionnaires. Spirometry, exhaled nitric oxide (FeNO), skin prick tests, total, and specific serum IgE analyses were performed along with the evaluation of home dust samples for the content in Der p 1 allergen. Three clusters were created on the basis of the presence/absence of wheeze in the last 12 months (Wh12m) and Der p 1-specific IgE level. Results: Cluster 1 (Wh12m+/high Der p 1 IgE) presented higher FeNO and poorer pulmonary function (lower FEV1 and FEF25%-75%), while its symptom score was not different from Cluster 2 (Wh12m+/low Der p 1 IgE). Cluster 3 (Wh12m-/low IgE) showed the lowest FeNO values and pulmonary function similar to Cluster 2. Within Cluster 1, both Der p 1-specific IgE and FeNO were positively correlated with dust Der p 1. Conclusions: Similar asthma phenotypes may occur in children despite differences in their atopic state. In atopic children, sensitizing allergens in the indoor environment may increase airway inflammation worsening pulmonary function. Moreover, environmental exposures may contribute to the development of asthma-like symptoms also in the absence of atopic sensitization, thus contributing to asthma overdiagnosis.
Lingua originaleEnglish
pagine (da-a)675-682
Numero di pagine8
RivistaPediatric Allergy and Immunology
Volume28
Stato di pubblicazionePublished - 2017

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Mites
Dust
Allergens
Immunoglobulin E
Multicenter Studies
Asthma
Phenotype
Dermatophagoides pteronyssinus
Indoor Air Pollution
Lung
Spirometry
Environmental Exposure
Skin Tests
Dermatophagoides pteronyssinus antigen p 1
Pneumonia
Nitric Oxide
Inflammation
Health
Serum

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

Cita questo

Sensitization to dust mite defines different phenotypes of asthma: A multicenter study. / Ferrante, Giuliana; Scaccianoce, Gianluca; Rizzo, Gianfranco; Colombo, Paolo; Cibella, Fabio; Cuttitta, Giuseppina; Drago, Gaspare; Zammit, Christopher; Bilocca, David; Ruggieri, Silvia; Longo, Valeria; Balzan, Martin; Montefort, Stephen; Viegi, Giovanni.

In: Pediatric Allergy and Immunology, Vol. 28, 2017, pag. 675-682.

Risultato della ricerca: Article

Ferrante, G, Scaccianoce, G, Rizzo, G, Colombo, P, Cibella, F, Cuttitta, G, Drago, G, Zammit, C, Bilocca, D, Ruggieri, S, Longo, V, Balzan, M, Montefort, S & Viegi, G 2017, 'Sensitization to dust mite defines different phenotypes of asthma: A multicenter study', Pediatric Allergy and Immunology, vol. 28, pagg. 675-682.
Ferrante, Giuliana ; Scaccianoce, Gianluca ; Rizzo, Gianfranco ; Colombo, Paolo ; Cibella, Fabio ; Cuttitta, Giuseppina ; Drago, Gaspare ; Zammit, Christopher ; Bilocca, David ; Ruggieri, Silvia ; Longo, Valeria ; Balzan, Martin ; Montefort, Stephen ; Viegi, Giovanni. / Sensitization to dust mite defines different phenotypes of asthma: A multicenter study. In: Pediatric Allergy and Immunology. 2017 ; Vol. 28. pagg. 675-682.
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title = "Sensitization to dust mite defines different phenotypes of asthma: A multicenter study",
abstract = "Background: Indoor allergens are risk factors for asthma: Thus, the characterization of indoor air quality is important for studying environment-health relationships in children. In particular, Dermatophagoides pteronyssinus is the dominant allergen for asthma. We cross-sectionally investigated the relationships among respiratory symptoms and function, airway inflammation, allergen sensitization, and indoor allergen concentration. Methods: One hundred and thirty-two children aging 10-14 years and living in a Southern Mediterranean area were evaluated by parental questionnaires. Spirometry, exhaled nitric oxide (FeNO), skin prick tests, total, and specific serum IgE analyses were performed along with the evaluation of home dust samples for the content in Der p 1 allergen. Three clusters were created on the basis of the presence/absence of wheeze in the last 12 months (Wh12m) and Der p 1-specific IgE level. Results: Cluster 1 (Wh12m+/high Der p 1 IgE) presented higher FeNO and poorer pulmonary function (lower FEV1 and FEF25{\%}-75{\%}), while its symptom score was not different from Cluster 2 (Wh12m+/low Der p 1 IgE). Cluster 3 (Wh12m-/low IgE) showed the lowest FeNO values and pulmonary function similar to Cluster 2. Within Cluster 1, both Der p 1-specific IgE and FeNO were positively correlated with dust Der p 1. Conclusions: Similar asthma phenotypes may occur in children despite differences in their atopic state. In atopic children, sensitizing allergens in the indoor environment may increase airway inflammation worsening pulmonary function. Moreover, environmental exposures may contribute to the development of asthma-like symptoms also in the absence of atopic sensitization, thus contributing to asthma overdiagnosis.",
author = "Giuliana Ferrante and Gianluca Scaccianoce and Gianfranco Rizzo and Paolo Colombo and Fabio Cibella and Giuseppina Cuttitta and Gaspare Drago and Christopher Zammit and David Bilocca and Silvia Ruggieri and Valeria Longo and Martin Balzan and Stephen Montefort and Giovanni Viegi",
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T1 - Sensitization to dust mite defines different phenotypes of asthma: A multicenter study

AU - Ferrante, Giuliana

AU - Scaccianoce, Gianluca

AU - Rizzo, Gianfranco

AU - Colombo, Paolo

AU - Cibella, Fabio

AU - Cuttitta, Giuseppina

AU - Drago, Gaspare

AU - Zammit, Christopher

AU - Bilocca, David

AU - Ruggieri, Silvia

AU - Longo, Valeria

AU - Balzan, Martin

AU - Montefort, Stephen

AU - Viegi, Giovanni

PY - 2017

Y1 - 2017

N2 - Background: Indoor allergens are risk factors for asthma: Thus, the characterization of indoor air quality is important for studying environment-health relationships in children. In particular, Dermatophagoides pteronyssinus is the dominant allergen for asthma. We cross-sectionally investigated the relationships among respiratory symptoms and function, airway inflammation, allergen sensitization, and indoor allergen concentration. Methods: One hundred and thirty-two children aging 10-14 years and living in a Southern Mediterranean area were evaluated by parental questionnaires. Spirometry, exhaled nitric oxide (FeNO), skin prick tests, total, and specific serum IgE analyses were performed along with the evaluation of home dust samples for the content in Der p 1 allergen. Three clusters were created on the basis of the presence/absence of wheeze in the last 12 months (Wh12m) and Der p 1-specific IgE level. Results: Cluster 1 (Wh12m+/high Der p 1 IgE) presented higher FeNO and poorer pulmonary function (lower FEV1 and FEF25%-75%), while its symptom score was not different from Cluster 2 (Wh12m+/low Der p 1 IgE). Cluster 3 (Wh12m-/low IgE) showed the lowest FeNO values and pulmonary function similar to Cluster 2. Within Cluster 1, both Der p 1-specific IgE and FeNO were positively correlated with dust Der p 1. Conclusions: Similar asthma phenotypes may occur in children despite differences in their atopic state. In atopic children, sensitizing allergens in the indoor environment may increase airway inflammation worsening pulmonary function. Moreover, environmental exposures may contribute to the development of asthma-like symptoms also in the absence of atopic sensitization, thus contributing to asthma overdiagnosis.

AB - Background: Indoor allergens are risk factors for asthma: Thus, the characterization of indoor air quality is important for studying environment-health relationships in children. In particular, Dermatophagoides pteronyssinus is the dominant allergen for asthma. We cross-sectionally investigated the relationships among respiratory symptoms and function, airway inflammation, allergen sensitization, and indoor allergen concentration. Methods: One hundred and thirty-two children aging 10-14 years and living in a Southern Mediterranean area were evaluated by parental questionnaires. Spirometry, exhaled nitric oxide (FeNO), skin prick tests, total, and specific serum IgE analyses were performed along with the evaluation of home dust samples for the content in Der p 1 allergen. Three clusters were created on the basis of the presence/absence of wheeze in the last 12 months (Wh12m) and Der p 1-specific IgE level. Results: Cluster 1 (Wh12m+/high Der p 1 IgE) presented higher FeNO and poorer pulmonary function (lower FEV1 and FEF25%-75%), while its symptom score was not different from Cluster 2 (Wh12m+/low Der p 1 IgE). Cluster 3 (Wh12m-/low IgE) showed the lowest FeNO values and pulmonary function similar to Cluster 2. Within Cluster 1, both Der p 1-specific IgE and FeNO were positively correlated with dust Der p 1. Conclusions: Similar asthma phenotypes may occur in children despite differences in their atopic state. In atopic children, sensitizing allergens in the indoor environment may increase airway inflammation worsening pulmonary function. Moreover, environmental exposures may contribute to the development of asthma-like symptoms also in the absence of atopic sensitization, thus contributing to asthma overdiagnosis.

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JO - Pediatric Allergy and Immunology

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SN - 0905-6157

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