Abstract
Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
Lingua originale | English |
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pagine (da-a) | 329-332 |
Numero di pagine | 4 |
Rivista | Dalton Transactions |
Volume | 46 |
Stato di pubblicazione | Published - 2017 |
All Science Journal Classification (ASJC) codes
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