Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Alessio Terenzi; Alessio Terenzi; Daniela Lötsch; Bernhard K. Keppler; null Dinhof; Walter Berger; Sushilla Van Schoonhoven; null Domarco; null Schreiber; Carlos Peinador; Marcos D. García

Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Alessio Terenzi, Alessio Terenzi, Daniela Lötsch, Bernhard K. Keppler, Dinhof, Walter Berger, Sushilla Van Schoonhoven, Domarco, Schreiber, Carlos Peinador, Marcos D. García

Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche

Risultato della ricerca: Article › peer review

29 Citazioni (Scopus)

Abstract

Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.

Lingua originale	English
pagine (da-a)	329-332
Numero di pagine	4
Rivista	Dalton Transactions
Volume	46
Stato di pubblicazione	Published - 2017

All Science Journal Classification (ASJC) codes

???subjectarea.asjc.1600.1604???

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Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells. / Terenzi, Alessio; Terenzi, Alessio; Lötsch, Daniela; Keppler, Bernhard K.; Dinhof; Berger, Walter; Van Schoonhoven, Sushilla; Domarco; Schreiber; Peinador, Carlos; García, Marcos D.

In: Dalton Transactions, Vol. 46, 2017, pag. 329-332.

Risultato della ricerca: Article › peer review

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abstract = "Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.",

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AU - Terenzi, Alessio

AU - Lötsch, Daniela

AU - Keppler, Bernhard K.

AU - Dinhof, null

AU - Berger, Walter

AU - Van Schoonhoven, Sushilla

AU - Domarco, null

AU - Schreiber, null

AU - Peinador, Carlos

AU - García, Marcos D.

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AB - Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.

UR - http://hdl.handle.net/10447/392738

UR - http://www.rsc.org/Publishing/Journals

M3 - Article

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EP - 332

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JF - Dalton Transactions

SN - 1477-9226

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Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Abstract

All Science Journal Classification (ASJC) codes

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