Self-assembled Pt2L2 boxes strongly bind G-quadruplex DNA and influence gene expression in cancer cells

Alessio Terenzi, Alessio Terenzi, Daniela Lötsch, Bernhard K. Keppler, Dinhof, Walter Berger, Sushilla Van Schoonhoven, Domarco, Schreiber, Carlos Peinador, Marcos D. García

Risultato della ricerca: Articlepeer review

29 Citazioni (Scopus)

Abstract

Supramolecular Pt(ii) quadrangular boxes bind native and G-quadruplex DNA motifs in a size-dependent fashion. Three Pt molecular squares of distinct size show biological activity against cancer cells and heavily influence the expression of genes known to form G-quadruplexes in their promoter regions. The smallest Pt-box displays less activity but more selectivity for a quadruplex formed in the c-Kit gene.
Lingua originaleEnglish
pagine (da-a)329-332
Numero di pagine4
RivistaDalton Transactions
Volume46
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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