Segmented relationships to model erosion ofregression effect in Cox regression

Risultato della ricerca: Articlepeer review

Abstract

In this article we propose a parsimonious parameterisation to model the so-called erosion of the covariate effect in the Cox model, namely a covariate effect approaching to zero as the follow-up time increases.The proposed parameterisation is based on the segmented relationship where proper constraints are set to accomodate for the erosion. Relevant hypothesis testing is discussed. The approach is illustrated on twohistorical datasets in the survival analysis literature, and some simulation studies are presented to show how the proposed framework leads to a test for a global effect with good power as compared with alternative procedures. Finally, possible generalisations are also presented for future research.
Lingua originaleEnglish
pagine (da-a)401-414
Numero di pagine14
RivistaStatistical Methods in Medical Research
Volume20
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Statistics and Probability
  • Health Information Management

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