Second-line chemotherapy in advanced pancreatic carcinoma: a multicenter survey of the Gruppo Oncologico Italia Meridionale on the activity and safety of the FOLFOX4 regimen in clinical practice.

Vittorio Gebbia, Di Cristina, Di Maggio, Nicolò Borsellino, Francesco Giuliani, Paolo Tralongo, Francesco Ferraù, Roberto Bordonaro, Verderame, Evaristo Maiello, Colucci, Michele Caruso

Risultato della ricerca: Article

47 Citazioni (Scopus)

Abstract

Background: In daily clinical practice second-line chemotherapy (SLCT) is frequently given to patients with advanced pancreatic cancer failing gemcitabine-based first-line chemotherapy without solid scientific support.Patients and methods: A retrospective survey was carried out including 42 patients. Patients received standard FOLFOX4 regimen biweekly until progression or unacceptable toxicity.Results: Six partial responses (14%) and 16 stabilizations (38%) were recorded for a tumor growth control rate of 57%. The median time to progression (TtP) was 4 months (range 1–7 months), and median overall survival (OS) was 6.7 months (range 2–9 months). A stabilization of performance status (PS) and a subjective improvement of cancer-related symptoms were recorded in 27 patients.Conclusions: Data presented in this paper support the use of FOLFOX4 regimen in the second-line treatment of adenocarcinoma of the pancreas patients. The use of SLCT, however, should be carefully proposed to patients with good PS or those who had a good response to first-line therapy.
Lingua originaleEnglish
pagine (da-a)124-127
Numero di pagine4
RivistaDefault journal
Volume18 suppl. 6
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology

Cita questo

Second-line chemotherapy in advanced pancreatic carcinoma: a multicenter survey of the Gruppo Oncologico Italia Meridionale on the activity and safety of the FOLFOX4 regimen in clinical practice. / Gebbia, Vittorio; Di Cristina; Di Maggio; Borsellino, Nicolò; Giuliani, Francesco; Tralongo, Paolo; Ferraù, Francesco; Bordonaro, Roberto; Verderame; Maiello, Evaristo; Colucci; Caruso, Michele.

In: Default journal, Vol. 18 suppl. 6, 2007, pag. 124-127.

Risultato della ricerca: Article

Gebbia, V, Di Cristina, Di Maggio, Borsellino, N, Giuliani, F, Tralongo, P, Ferraù, F, Bordonaro, R, Verderame, Maiello, E, Colucci & Caruso, M 2007, 'Second-line chemotherapy in advanced pancreatic carcinoma: a multicenter survey of the Gruppo Oncologico Italia Meridionale on the activity and safety of the FOLFOX4 regimen in clinical practice.', Default journal, vol. 18 suppl. 6, pagg. 124-127.
Gebbia, Vittorio ; Di Cristina ; Di Maggio ; Borsellino, Nicolò ; Giuliani, Francesco ; Tralongo, Paolo ; Ferraù, Francesco ; Bordonaro, Roberto ; Verderame ; Maiello, Evaristo ; Colucci ; Caruso, Michele. / Second-line chemotherapy in advanced pancreatic carcinoma: a multicenter survey of the Gruppo Oncologico Italia Meridionale on the activity and safety of the FOLFOX4 regimen in clinical practice. In: Default journal. 2007 ; Vol. 18 suppl. 6. pagg. 124-127.
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abstract = "Background: In daily clinical practice second-line chemotherapy (SLCT) is frequently given to patients with advanced pancreatic cancer failing gemcitabine-based first-line chemotherapy without solid scientific support.Patients and methods: A retrospective survey was carried out including 42 patients. Patients received standard FOLFOX4 regimen biweekly until progression or unacceptable toxicity.Results: Six partial responses (14{\%}) and 16 stabilizations (38{\%}) were recorded for a tumor growth control rate of 57{\%}. The median time to progression (TtP) was 4 months (range 1–7 months), and median overall survival (OS) was 6.7 months (range 2–9 months). A stabilization of performance status (PS) and a subjective improvement of cancer-related symptoms were recorded in 27 patients.Conclusions: Data presented in this paper support the use of FOLFOX4 regimen in the second-line treatment of adenocarcinoma of the pancreas patients. The use of SLCT, however, should be carefully proposed to patients with good PS or those who had a good response to first-line therapy.",
author = "Vittorio Gebbia and {Di Cristina} and {Di Maggio} and Nicol{\`o} Borsellino and Francesco Giuliani and Paolo Tralongo and Francesco Ferra{\`u} and Roberto Bordonaro and Verderame and Evaristo Maiello and Colucci and Michele Caruso",
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T1 - Second-line chemotherapy in advanced pancreatic carcinoma: a multicenter survey of the Gruppo Oncologico Italia Meridionale on the activity and safety of the FOLFOX4 regimen in clinical practice.

AU - Gebbia, Vittorio

AU - Di Cristina, null

AU - Di Maggio, null

AU - Borsellino, Nicolò

AU - Giuliani, Francesco

AU - Tralongo, Paolo

AU - Ferraù, Francesco

AU - Bordonaro, Roberto

AU - Verderame, null

AU - Maiello, Evaristo

AU - Colucci, null

AU - Caruso, Michele

PY - 2007

Y1 - 2007

N2 - Background: In daily clinical practice second-line chemotherapy (SLCT) is frequently given to patients with advanced pancreatic cancer failing gemcitabine-based first-line chemotherapy without solid scientific support.Patients and methods: A retrospective survey was carried out including 42 patients. Patients received standard FOLFOX4 regimen biweekly until progression or unacceptable toxicity.Results: Six partial responses (14%) and 16 stabilizations (38%) were recorded for a tumor growth control rate of 57%. The median time to progression (TtP) was 4 months (range 1–7 months), and median overall survival (OS) was 6.7 months (range 2–9 months). A stabilization of performance status (PS) and a subjective improvement of cancer-related symptoms were recorded in 27 patients.Conclusions: Data presented in this paper support the use of FOLFOX4 regimen in the second-line treatment of adenocarcinoma of the pancreas patients. The use of SLCT, however, should be carefully proposed to patients with good PS or those who had a good response to first-line therapy.

AB - Background: In daily clinical practice second-line chemotherapy (SLCT) is frequently given to patients with advanced pancreatic cancer failing gemcitabine-based first-line chemotherapy without solid scientific support.Patients and methods: A retrospective survey was carried out including 42 patients. Patients received standard FOLFOX4 regimen biweekly until progression or unacceptable toxicity.Results: Six partial responses (14%) and 16 stabilizations (38%) were recorded for a tumor growth control rate of 57%. The median time to progression (TtP) was 4 months (range 1–7 months), and median overall survival (OS) was 6.7 months (range 2–9 months). A stabilization of performance status (PS) and a subjective improvement of cancer-related symptoms were recorded in 27 patients.Conclusions: Data presented in this paper support the use of FOLFOX4 regimen in the second-line treatment of adenocarcinoma of the pancreas patients. The use of SLCT, however, should be carefully proposed to patients with good PS or those who had a good response to first-line therapy.

UR - http://hdl.handle.net/10447/17598

M3 - Article

VL - 18 suppl. 6

SP - 124

EP - 127

JO - Default journal

JF - Default journal

ER -