Search for genetic factors associated with susceptibility to multiple sclerosis.

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22 Citazioni (Scopus)

Abstract

Multiple sclerosis (MS) is a cell-mediated autoimmune disease characterized by type-1 cytokine production.Environmental and individual genetic background might influence this response particularly in cytokine gene polymorphisms. We evaluated whether polymorphisms of interleukin (IL)-10, IL-12, and tumor necrosis factor (TNF)-α genes, which might play a role in MS pathogenesis, are associated with MS susceptibility. Genotype frequencies for all the analyzed polymorphisms were not differently distributed between cases and controls. It is reasonable to suppose that the cytokine single-nucleotide polymorphisms (SNPs) studied must be considered against a larger genetic background involving other functional SNPs of Th1 regulator elements such as IL-21 and IL-23.
Lingua originaleEnglish
pagine (da-a)264-269
Numero di pagine6
RivistaAnnals of the New York Academy of Sciences
Volume1067
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1300???
  • History and Philosophy of Science

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