Salvage treatment with ganciclovir in a splenectomized, polytransfused patient affected by systemic inflammatory response syndrome

Gaspare Parrinello, Giuseppe Licata, Daniele Torres, Bellanca, Virzi', Marrone, Francesco Cuttitta, Petrantoni, Parrinello, Pizzo

Risultato della ricerca: Article

1 Citazione (Scopus)

Abstract

A 23-year-old man was admitted to hospital with a 12-day history of daily fever. A clinical history revealed that 10 months previously, the patient had been splenectomized and polytransfused for a severe blunt trauma. On admission, laboratory data revealed significant leukocytosis (33,230/ul). The patient's general clinical conditions rapidly worsened into a severe systemic inflammatory response syndrome in four days. After 10 days of broad-spectrum antibiotic treatment, the temperature curve was unmodified and severe leukocytosis persisted (44,300 ul) with absolute lymphocytosis. Laboratory tests ruled out hematological diseases, pneumonia, abscesses and endocarditis. In the light of IgM positivity for CMV (unconfirmed by PCR) and with the support of a PubMed search, we commenced a salvage treatment with intravenous ganciclovir, suspecting a viral infection or reactivation. After two days of therapy, an immediate defervescence was observed with a remarkable clinical improvement. After 10 days, the clinical syndrome had been completely resolved and the patient was discharged in good, general clinical health.
Lingua originaleEnglish
pagine (da-a)267-272
Numero di pagine6
RivistaInternational Journal of Immunopathology and Pharmacology
Volume27
Stato di pubblicazionePublished - 2014

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Salvage Therapy
Systemic Inflammatory Response Syndrome
Ganciclovir
Leukocytosis
Lymphocytosis
Hematologic Diseases
Virus Diseases
Endocarditis
PubMed
Abscess
Immunoglobulin M
Pneumonia
Fever
Anti-Bacterial Agents
Polymerase Chain Reaction
Temperature
Health
Wounds and Injuries
Therapeutics

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cita questo

Salvage treatment with ganciclovir in a splenectomized, polytransfused patient affected by systemic inflammatory response syndrome. / Parrinello, Gaspare; Licata, Giuseppe; Torres, Daniele; Bellanca; Virzi'; Marrone; Cuttitta, Francesco; Petrantoni; Parrinello; Pizzo.

In: International Journal of Immunopathology and Pharmacology, Vol. 27, 2014, pag. 267-272.

Risultato della ricerca: Article

Parrinello, Gaspare ; Licata, Giuseppe ; Torres, Daniele ; Bellanca ; Virzi' ; Marrone ; Cuttitta, Francesco ; Petrantoni ; Parrinello ; Pizzo. / Salvage treatment with ganciclovir in a splenectomized, polytransfused patient affected by systemic inflammatory response syndrome. In: International Journal of Immunopathology and Pharmacology. 2014 ; Vol. 27. pagg. 267-272.
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abstract = "A 23-year-old man was admitted to hospital with a 12-day history of daily fever. A clinical history revealed that 10 months previously, the patient had been splenectomized and polytransfused for a severe blunt trauma. On admission, laboratory data revealed significant leukocytosis (33,230/ul). The patient's general clinical conditions rapidly worsened into a severe systemic inflammatory response syndrome in four days. After 10 days of broad-spectrum antibiotic treatment, the temperature curve was unmodified and severe leukocytosis persisted (44,300 ul) with absolute lymphocytosis. Laboratory tests ruled out hematological diseases, pneumonia, abscesses and endocarditis. In the light of IgM positivity for CMV (unconfirmed by PCR) and with the support of a PubMed search, we commenced a salvage treatment with intravenous ganciclovir, suspecting a viral infection or reactivation. After two days of therapy, an immediate defervescence was observed with a remarkable clinical improvement. After 10 days, the clinical syndrome had been completely resolved and the patient was discharged in good, general clinical health.",
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T1 - Salvage treatment with ganciclovir in a splenectomized, polytransfused patient affected by systemic inflammatory response syndrome

AU - Parrinello, Gaspare

AU - Licata, Giuseppe

AU - Torres, Daniele

AU - Bellanca, null

AU - Virzi', null

AU - Marrone, null

AU - Cuttitta, Francesco

AU - Petrantoni, null

AU - Parrinello, null

AU - Pizzo, null

PY - 2014

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N2 - A 23-year-old man was admitted to hospital with a 12-day history of daily fever. A clinical history revealed that 10 months previously, the patient had been splenectomized and polytransfused for a severe blunt trauma. On admission, laboratory data revealed significant leukocytosis (33,230/ul). The patient's general clinical conditions rapidly worsened into a severe systemic inflammatory response syndrome in four days. After 10 days of broad-spectrum antibiotic treatment, the temperature curve was unmodified and severe leukocytosis persisted (44,300 ul) with absolute lymphocytosis. Laboratory tests ruled out hematological diseases, pneumonia, abscesses and endocarditis. In the light of IgM positivity for CMV (unconfirmed by PCR) and with the support of a PubMed search, we commenced a salvage treatment with intravenous ganciclovir, suspecting a viral infection or reactivation. After two days of therapy, an immediate defervescence was observed with a remarkable clinical improvement. After 10 days, the clinical syndrome had been completely resolved and the patient was discharged in good, general clinical health.

AB - A 23-year-old man was admitted to hospital with a 12-day history of daily fever. A clinical history revealed that 10 months previously, the patient had been splenectomized and polytransfused for a severe blunt trauma. On admission, laboratory data revealed significant leukocytosis (33,230/ul). The patient's general clinical conditions rapidly worsened into a severe systemic inflammatory response syndrome in four days. After 10 days of broad-spectrum antibiotic treatment, the temperature curve was unmodified and severe leukocytosis persisted (44,300 ul) with absolute lymphocytosis. Laboratory tests ruled out hematological diseases, pneumonia, abscesses and endocarditis. In the light of IgM positivity for CMV (unconfirmed by PCR) and with the support of a PubMed search, we commenced a salvage treatment with intravenous ganciclovir, suspecting a viral infection or reactivation. After two days of therapy, an immediate defervescence was observed with a remarkable clinical improvement. After 10 days, the clinical syndrome had been completely resolved and the patient was discharged in good, general clinical health.

KW - ganciclovir

KW - inflammatory response

UR - http://hdl.handle.net/10447/100593

M3 - Article

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SP - 267

EP - 272

JO - International Journal of Immunopathology and Pharmacology

JF - International Journal of Immunopathology and Pharmacology

SN - 0394-6320

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