Salvage re-irradiation options in adult medulloblastoma: A case report and review of the literature

Antonio Lo Casto, Gianluca Mortellaro, Giuseppe Ferrera, Francesco Cuccia, Lucia Ognibene, Giuseppe Craparo, Gabriella Ferrera, Giuseppe Craparo

Risultato della ricerca: Articlepeer review


Background/Aim: Medulloblastoma is a rare tumor of adult age, while it occurs more frequently in children. Given the rarity, there is a lack of evidence for the treatment of recurrent disease. Few data are available about salvage reirradiation collecting very heterogeneous series. Case Report: A 51-year-old male presented with headache, nausea, double vision, and gait disorders. A contrast-enhanced brain-MRI showed the presence of multifocal medulloblastoma. After surgery, adjuvant craniospinal radiotherapy was performed, chemotherapy was stopped due to toxicity. After 27 months, a new MRI and a Methionine-PET revealed a late pontocerebellar relapse; multidisciplinary board decided for a SBRT treatment. The second course of RT was well tolerated and 14 months later, the patient is alive in good general conditions, with no evidence of disease. Conclusion: Our experience supports the use of salvage stereotactic radiotherapy as a safe and effective treatment option.
Lingua originaleEnglish
pagine (da-a)1283-1288
Numero di pagine6
RivistaIn Vivo
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3000.3004???


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