Salmeterol Xinafoate (SX) loaded into mucoadhesive solid lipid microparticles for COPD treatment

Erika Amore, Serena Di Vincenzo, Gaetano Giammona, Maria Luisa Bondì, Maria Ferraro, Serena Di Vincenzo, Mark Gjomarkaj, Erika Amore, Maria Luisa Bondì, Valeria La Parola, Elisabetta Pace, Donatella Valenti, Maria Letizia Manca, Maria Elisabetta Pace, Maria Luisa Bondi', Valeria La Parola

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)


Chronic obstructive pulmonary disease (COPD) is one of the main health problems worldwide. It is characterised by chronic inflammation in the lungs that leads to progressive, chronic, largely irreversible airflow obstruction. The use of long-acting β agonists remain today the frontline treatment for COPD with the aim of minimizing side effects and enhancing therapeutic usefulness. To this purpose, in this paper, mucoadhesive solid lipid microparticles (SLMs) containing a long-acting β-2 agonist, Salmeterol Xinafoate (SX) were prepared, characterised (size, z-potential, aerodynamic diameter, turbidimetric evaluations, drug loading and entrapping efficiency) and tested in a model of bronchial epithelial cells. It was demonstrated that the incorporation of SX into SLMs led to the production of particles suitable for inhalation and more efficient than the free molecule at increasing the cAMP expression in bronchial epithelial cells. In conclusion, the prepared systems, due to their aerodynamic behaviour and mucoadhesive properties, could improve the retention time of SX in the lung epithelium and its therapeutic effect, thus representing a good strategy for the treatment of COPD patients.
Lingua originaleEnglish
pagine (da-a)351-358
Numero di pagine8
RivistaInternational Journal of Pharmaceutics
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.3000.3003???


Entra nei temi di ricerca di 'Salmeterol Xinafoate (SX) loaded into mucoadhesive solid lipid microparticles for COPD treatment'. Insieme formano una fingerprint unica.

Cita questo