Safety and efficacy of intra-articular anti-tumor necrosis factor α agents compared to corticosteroids in a treat-to-target strategy in patients with inflammatory arthritis and monoarthritis flare

Giovanni Triolo, Francesco Ciccia, Vasiliki Liakouli, Armando Conchiglia, Francesco Carubbi, Piero Ruscitti, Lorenzo Gregori, Maria Letizia Pistoia, Cristino Danniballe, Luigi Zugaro, Carlo Masciocchi, Roberto Giacomelli, Paola Cipriani

    Risultato della ricerca: Articlepeer review

    20 Citazioni (Scopus)

    Abstract

    The aim of this study was to assess safety and efficacy of ultrasonography (US)-guided intra-articular injections using tumor necrosis factor (TNF) blockers compared to corticosteroids in rheumatoid arthritis (RA) or psoriatic arthritis (PsA) patients, experiencing refractory monoarthritis despite the current systemic therapy. Eighty-two patients were randomized to receive three intra-articular injections monthly of either corticosteroid or TNF blockers. Primary endpoints were the safety and an improvement greater than 20% for visual analogic scales of involved joint pain in patients injected with anti-TNFα. Further clinical, US, and magnetic resonance imaging (MRI) evaluations were considered secondary endpoints. Intra-articular TNF blockers are a safe strategy, determining a significant reduction of patient and physician reported clinical outcomes and US/MRI scores, in RA and PsA patients, when compared to intra-articular injections of corticosteroids. US guidance excluded the possibility to inject the drug in the wrong site, maximizing local effects, reducing systemic effects, and increasing the safety of the procedure. Patients with inflammatory monoarthritis could be successfully treated with US-guided intra-articular TNF blockers that are a safe and well tolerated procedure, to achieve a longstanding clinical and radiological good clinical response and/or disease remission.
    Lingua originaleEnglish
    pagine (da-a)252-266
    Numero di pagine15
    RivistaInternational Journal of Immunopathology and Pharmacology
    Volume29
    Stato di pubblicazionePublished - 2015

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology
    • Pharmacology

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