rs629301 CELSR2 polymorphism confers a ten-year equivalent risk of critical stenosis assessed by coronary angiography

Maurizio Averna, Salvatore Novo, Chiara Scrimali, Gabriella Misiano, Davide Noto, Grazia Ida Altieri, Valeria Ingrassia, Federica Brucato, Carlo Maria Barbagallo, Rossella Spina, Angelo Baldassare Cefalu', Antonina Giammanco, Filippo Sarullo, Oliviero Olivieri, Domenico Girelli, Nicola Martinelli, Vincenzo Pernice, Davide Nicola Girelli, Francesca Fayer, Valentina Pernice

Risultato della ricerca: Articlepeer review

Abstract

Background and aims: Novel genetic determinants associated with coronary artery disease (CAD) have been discovered by genome wide association studies. Variants encompassing the CELSR2- PSRC1-SORT1 gene cluster have been associated with CAD. This study is aimed to investigate the rs629301 polymorphism association with the extent of CAD evaluated by coronary angiography (CAG), and to evaluate its associations with an extensive panel of lipid and lipoprotein measurements in a large Italian cohort of 2429 patients. Methods and results: The patients were collected by four Intensive Care Units located in Palermo and Verona (Italy). Clinical Records were filed, blood samples were collected, lipids and apolipoproteins (apo) were measured in separate laboratories. CAD was defined by the presence of stenotic arteries (>50% lumen diameter) by CAG. The presence of CAD was associated with the rs629301 genotype. Patients with CAD were 78% and 73% (p = 0.007) of the T/T vs. T/G + G/G genotype carriers respectively. T/T genotype was also correlated with the number of stenotic arteries, with a 1.29 (1.04–1.61) risk to have a three-arteries disease. T/T genotype correlated with higher levels of LDL-, non-HDL cholesterol, apoB, apoE and apoCIII, and lower HDL-cholesterol. Logistic Regression confirmed that rs629301was associated with CAD independently from the common risk factors, with a risk similar to that conferred by ten years of age [odds ratios were 1.43 (1.04–1.96) and 1.39 (1.22–1.58) respectively]. Conclusions: rs629301 risk allele was independently associated with the extension and severity of CAD and positively with apoE and apoB containing lipoproteins.
Lingua originaleEnglish
pagine (da-a)1542-1547
Numero di pagine6
RivistaNMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
Volume31
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.2700.2701???
  • ???subjectarea.asjc.2700.2712???
  • ???subjectarea.asjc.2900.2916???
  • ???subjectarea.asjc.2700.2705???

Fingerprint

Entra nei temi di ricerca di 'rs629301 CELSR2 polymorphism confers a ten-year equivalent risk of critical stenosis assessed by coronary angiography'. Insieme formano una fingerprint unica.

Cita questo