TY - JOUR
T1 - Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
AU - Montalto, Giuseppe
AU - Yang, Li V.
AU - Cervello, Melchiorre
AU - Martelli, Alberto M.
AU - Dulinska-Litewka, Joanna
AU - Fitzgerald, Timothy L.
AU - Candido, Saverio
AU - Nicoletti, Ferdinando
AU - Falzone, Luca
AU - Gizak, Agnieszka
AU - Lertpiriyapong, Kvin
AU - Rakus, Dariusz
AU - Libra, Massimo
AU - Steelman, Linda S.
AU - Laidler, Piotr
AU - Mccubrey, James A.
AU - Neri, Luca M.
AU - Cocco, Lucio
AU - Montalto, Giuseppe
AU - Abrams, Stephen L.
PY - 2017
Y1 - 2017
N2 - Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 pathways elicit essential regulatory influences on cancer initiation, EMT and progression. A common kinase involved in all these pathways is moon-lighting kinase glycogen synthase kinase-3 (GSK-3). These pathways are also regulated by micro-RNAs (miRs). TP53 and components of these pathways can regulate the expression of miRs. Targeting members of these pathways may improve cancer therapy in those malignancies that display their abnormal regulation. This review will discuss the interactions of the multi-functional GSK-3 enzyme in the Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, Hh, Notch and TP53 pathways. The regulation of these pathways by miRs and their effects on CSC generation, EMT, invasion and metastasis will be discussed.
AB - Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 pathways elicit essential regulatory influences on cancer initiation, EMT and progression. A common kinase involved in all these pathways is moon-lighting kinase glycogen synthase kinase-3 (GSK-3). These pathways are also regulated by micro-RNAs (miRs). TP53 and components of these pathways can regulate the expression of miRs. Targeting members of these pathways may improve cancer therapy in those malignancies that display their abnormal regulation. This review will discuss the interactions of the multi-functional GSK-3 enzyme in the Wnt/beta-catenin, PI3K/PTEN/Akt/mTORC, Ras/Raf/MEK/ERK, Hh, Notch and TP53 pathways. The regulation of these pathways by miRs and their effects on CSC generation, EMT, invasion and metastasis will be discussed.
UR - http://hdl.handle.net/10447/251673
UR - http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=13991&path%5B%5D=44599
M3 - Article
VL - 8
SP - 14221
EP - 14250
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
ER -