Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

Viviana Bazan, Valentina Calo', Nadia Barraco, Giuseppe Badalamenti, Daniele Fanale, Lorena Incorvaia, Antonio Russo, Angela Listi', Lorena Incorvaia, Antonio Russo, Angela Listì, Rossella Maragliano, Nadia Barraco, Daniele Fanale, Giuseppe Badalamenti, Viviana Bazan, Valentina Calò, Bruno Vincenzi, Juan Lucio Iovanna

Risultato della ricerca: Articlepeer review

109 Citazioni (Scopus)

Abstract

In recent years, multiple strategies for eliciting anti-tumor immunity have been developed in different clinical studies. Currently, immunotherapy was clinically validated as effective treatment option for many tumors such as melanoma, non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC). Some surface receptors of immune cells, called immune checkpoint receptors, may inhibit activity of proinflammatory lymphocytes, following binding with specific ligands. Cancer cells exploit these mechanisms to inactivate tumor-infiltrating lymphocytes (TILs) to escape from immunosurveillance. Among the different tumor-infiltrating immune cell populations, including leucocytes, macrophages, dendritic cells and mast cells, TILs are considered a selected population of T-cells with a higher specific immunological reactivity against tumor cells than the non-infiltrating lymphocytes. In this review we will discuss the promising role of TILs as biomarkers reflecting the immune response to the tumor, describing their potential ability to predict the prognosis and clinical outcome of immunotherapy in some solid tumors.
Lingua originaleEnglish
Numero di pagine8
RivistaCellular Immunology
Volume343
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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