Role of TLR Polymorphisms in Aging and Age-Related Diseases

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Abstract

Innate immunity provides the first line of host defense against infection byrecognizing and killing microbes, and simultaneously activating an instructiveimmune response. Toll-like receptors (TLRs) are principal mediators of rapidmicrobial recognition, and they mainly function by detecting exogenouspathogen-associated molecular patterns. Recognition of their ligands activessignaling ways, which culminate in evocating acute host responses, involved inkilling pathogens. Here, we describe the involvement of TLR4 polymorphisms inaging, and particularly in immunosenescence and age-related diseases,suggesting the crucial role of molecules of innate immunity in the pathophysiologyof these diseases. Accordingly, we observed that proinflammatory allelesmay be related to unsuccessful aging, such as Alzheimer’s disease, prostatecancer, diabetes, cardiovascular diseases (i.e., atherosclerosis, aneurysm), andthe anti-inflammatory alleles may reciprocally result in increased longevity andsuccessful aging. Finally, a possible therapeutic approach to delay age-relateddiseases is outlined.
Lingua originaleEnglish
Titolo della pubblicazione ospiteHandbook of Immunosenescence
Pagine1-18
Numero di pagine18
Stato di pubblicazionePublished - 2017

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