Thoracic aortic aneurysm (TAA) is a progressive disorder involving gradual dilation of ascending and/or descending thoracic aortawith dissection or rupture as complications. It occurs as sporadic or defined syndromes/familial forms.Genetic, molecular andcellular mechanims of sporadic TAA forms are poorly characterized and known.Thus, our interest has been focused on investigatingthe role of genetic variants of transforming growth factor-beta (TGF-beta) pathways in TAA risk. On the other hand, no data on the role ofgenetic variants of TGF-beta pathway in sporadic TAA exist until now. In addition, other cytokines, including IL-10, orchestrate TAApathophysiology. Their balance determines the ultimate fate of the aortic wall as healing atherosclerosis or aneurysm formation.Thus, in this paper it was analyzed the role of ten polymorphisms of genes encoding TGF-beta isoforms and receptors, and IL-10 insporadic TAA. Our study included cases affected by sporadic TAA and two control groups. The most relevant finding obtainedallows us to propose that rs900 TGF-beta2 SNP is associated with sporadic TAA in women. This might open new perspectives for theanalysis of sporadic TAA susceptibility factors and prevention.
|Numero di pagine||8|
|Rivista||Mediators of Inflammation|
|Stato di pubblicazione||Published - 2014|
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