Role of prophylactic central neck dissection in cN0-papillary thyroid carcinoma: Results from a high-prevalence area

Sebastiano Bonventre, Giuseppe Modica, Gaspare Gulotta, Cristina Raspanti, Silvia Di Giovanni, Angela Inviati, Andrea Attard, Giuseppina Irene Melfa, Gregorio Scerrino, Sebastiano Bonventre, Gaspare Gulotta, Giuseppe Modica, Marco Attard, Andrea Attard, Angela Inviati, Cristina Raspanti, Giuseppina Irene Melfa, Sergio Mazzola, Silvia Di Giovanni

Risultato della ricerca: Article

7 Citazioni (Scopus)

Abstract

BACKGROUND: Prophylactic, compartment-oriented central neck dissection (CND) for cN0 papillary thyroid carcinoma (PTC) is not widely practiced. We examined our results with this surgical approach. METHODS: A cohort of 158 patients operated on for the classical variant of PTC at a follow-up of 1-22 years (mean: 6.6) were enrolled. The patients with a preoperative diagnosis of cN0 PTC (group A, 59 patients) underwent total thyroidectomy (TT) + CND. In the patients with incidental postoperative diagnosis of malignancy (group B, 99 patients) a TT alone was performed. RESULTS: Ninety-six T1, 36 T2, 26 T3/T4 PTC patients were enrolled. The overall biochemical/scintigraphic recurrence rate (15 patients, 9.49%), was significantly higher in group B. Disease-free survival and need for postoperative radioiodine ablative treatment were more favorable in group A (P<0.05; P<0.001, respectively). The median radioiodine ablative treatment in the T2 cluster alone was lower in group A (P<0.001). The morbidity rate was similar in both groups. CONCLUSION: Considering the acceptable morbidity, prophylactic CND seems to be advantageous in terms of recurrence rate and need for radioiodine treatment in this variant of PTC, at least in T2 or more advanced stages. The indolent behavior of PTC does not allow for reliable prognostic evaluations.
Lingua originaleEnglish
pagine (da-a)159-167
Numero di pagine9
RivistaDefault journal
Volume71
Stato di pubblicazionePublished - 2016

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Neck Dissection
Thyroidectomy
Morbidity
Recurrence
Papillary Thyroid cancer
Disease-Free Survival
Therapeutics
Neoplasms

All Science Journal Classification (ASJC) codes

  • Surgery

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Role of prophylactic central neck dissection in cN0-papillary thyroid carcinoma: Results from a high-prevalence area. / Bonventre, Sebastiano; Modica, Giuseppe; Gulotta, Gaspare; Raspanti, Cristina; Di Giovanni, Silvia; Inviati, Angela; Attard, Andrea; Melfa, Giuseppina Irene; Scerrino, Gregorio; Bonventre, Sebastiano; Gulotta, Gaspare; Modica, Giuseppe; Attard, Marco; Attard, Andrea; Inviati, Angela; Raspanti, Cristina; Melfa, Giuseppina Irene; Mazzola, Sergio; Di Giovanni, Silvia.

In: Default journal, Vol. 71, 2016, pag. 159-167.

Risultato della ricerca: Article

Bonventre, S, Modica, G, Gulotta, G, Raspanti, C, Di Giovanni, S, Inviati, A, Attard, A, Melfa, GI, Scerrino, G, Bonventre, S, Gulotta, G, Modica, G, Attard, M, Attard, A, Inviati, A, Raspanti, C, Melfa, GI, Mazzola, S & Di Giovanni, S 2016, 'Role of prophylactic central neck dissection in cN0-papillary thyroid carcinoma: Results from a high-prevalence area', Default journal, vol. 71, pagg. 159-167.
Bonventre, Sebastiano ; Modica, Giuseppe ; Gulotta, Gaspare ; Raspanti, Cristina ; Di Giovanni, Silvia ; Inviati, Angela ; Attard, Andrea ; Melfa, Giuseppina Irene ; Scerrino, Gregorio ; Bonventre, Sebastiano ; Gulotta, Gaspare ; Modica, Giuseppe ; Attard, Marco ; Attard, Andrea ; Inviati, Angela ; Raspanti, Cristina ; Melfa, Giuseppina Irene ; Mazzola, Sergio ; Di Giovanni, Silvia. / Role of prophylactic central neck dissection in cN0-papillary thyroid carcinoma: Results from a high-prevalence area. In: Default journal. 2016 ; Vol. 71. pagg. 159-167.
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abstract = "BACKGROUND: Prophylactic, compartment-oriented central neck dissection (CND) for cN0 papillary thyroid carcinoma (PTC) is not widely practiced. We examined our results with this surgical approach. METHODS: A cohort of 158 patients operated on for the classical variant of PTC at a follow-up of 1-22 years (mean: 6.6) were enrolled. The patients with a preoperative diagnosis of cN0 PTC (group A, 59 patients) underwent total thyroidectomy (TT) + CND. In the patients with incidental postoperative diagnosis of malignancy (group B, 99 patients) a TT alone was performed. RESULTS: Ninety-six T1, 36 T2, 26 T3/T4 PTC patients were enrolled. The overall biochemical/scintigraphic recurrence rate (15 patients, 9.49{\%}), was significantly higher in group B. Disease-free survival and need for postoperative radioiodine ablative treatment were more favorable in group A (P<0.05; P<0.001, respectively). The median radioiodine ablative treatment in the T2 cluster alone was lower in group A (P<0.001). The morbidity rate was similar in both groups. CONCLUSION: Considering the acceptable morbidity, prophylactic CND seems to be advantageous in terms of recurrence rate and need for radioiodine treatment in this variant of PTC, at least in T2 or more advanced stages. The indolent behavior of PTC does not allow for reliable prognostic evaluations.",
author = "Sebastiano Bonventre and Giuseppe Modica and Gaspare Gulotta and Cristina Raspanti and {Di Giovanni}, Silvia and Angela Inviati and Andrea Attard and Melfa, {Giuseppina Irene} and Gregorio Scerrino and Sebastiano Bonventre and Gaspare Gulotta and Giuseppe Modica and Marco Attard and Andrea Attard and Angela Inviati and Cristina Raspanti and Melfa, {Giuseppina Irene} and Sergio Mazzola and {Di Giovanni}, Silvia",
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T1 - Role of prophylactic central neck dissection in cN0-papillary thyroid carcinoma: Results from a high-prevalence area

AU - Bonventre, Sebastiano

AU - Modica, Giuseppe

AU - Gulotta, Gaspare

AU - Raspanti, Cristina

AU - Di Giovanni, Silvia

AU - Inviati, Angela

AU - Attard, Andrea

AU - Melfa, Giuseppina Irene

AU - Scerrino, Gregorio

AU - Bonventre, Sebastiano

AU - Gulotta, Gaspare

AU - Modica, Giuseppe

AU - Attard, Marco

AU - Attard, Andrea

AU - Inviati, Angela

AU - Raspanti, Cristina

AU - Melfa, Giuseppina Irene

AU - Mazzola, Sergio

AU - Di Giovanni, Silvia

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Prophylactic, compartment-oriented central neck dissection (CND) for cN0 papillary thyroid carcinoma (PTC) is not widely practiced. We examined our results with this surgical approach. METHODS: A cohort of 158 patients operated on for the classical variant of PTC at a follow-up of 1-22 years (mean: 6.6) were enrolled. The patients with a preoperative diagnosis of cN0 PTC (group A, 59 patients) underwent total thyroidectomy (TT) + CND. In the patients with incidental postoperative diagnosis of malignancy (group B, 99 patients) a TT alone was performed. RESULTS: Ninety-six T1, 36 T2, 26 T3/T4 PTC patients were enrolled. The overall biochemical/scintigraphic recurrence rate (15 patients, 9.49%), was significantly higher in group B. Disease-free survival and need for postoperative radioiodine ablative treatment were more favorable in group A (P<0.05; P<0.001, respectively). The median radioiodine ablative treatment in the T2 cluster alone was lower in group A (P<0.001). The morbidity rate was similar in both groups. CONCLUSION: Considering the acceptable morbidity, prophylactic CND seems to be advantageous in terms of recurrence rate and need for radioiodine treatment in this variant of PTC, at least in T2 or more advanced stages. The indolent behavior of PTC does not allow for reliable prognostic evaluations.

AB - BACKGROUND: Prophylactic, compartment-oriented central neck dissection (CND) for cN0 papillary thyroid carcinoma (PTC) is not widely practiced. We examined our results with this surgical approach. METHODS: A cohort of 158 patients operated on for the classical variant of PTC at a follow-up of 1-22 years (mean: 6.6) were enrolled. The patients with a preoperative diagnosis of cN0 PTC (group A, 59 patients) underwent total thyroidectomy (TT) + CND. In the patients with incidental postoperative diagnosis of malignancy (group B, 99 patients) a TT alone was performed. RESULTS: Ninety-six T1, 36 T2, 26 T3/T4 PTC patients were enrolled. The overall biochemical/scintigraphic recurrence rate (15 patients, 9.49%), was significantly higher in group B. Disease-free survival and need for postoperative radioiodine ablative treatment were more favorable in group A (P<0.05; P<0.001, respectively). The median radioiodine ablative treatment in the T2 cluster alone was lower in group A (P<0.001). The morbidity rate was similar in both groups. CONCLUSION: Considering the acceptable morbidity, prophylactic CND seems to be advantageous in terms of recurrence rate and need for radioiodine treatment in this variant of PTC, at least in T2 or more advanced stages. The indolent behavior of PTC does not allow for reliable prognostic evaluations.

UR - http://hdl.handle.net/10447/206939

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M3 - Article

VL - 71

SP - 159

EP - 167

JO - Default journal

JF - Default journal

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