Role of oxidative stress in neonatal respiratory distress syndrome

Giovanni Corsello, Gabriella D'Angelo, Roberta Granese, Eloisa Gitto, Raffaele Falsaperla, Russel J. Reiter, Lucia Marseglia, Raffaele Falsaperla

Risultato della ricerca: Articlepeer review

12 Citazioni (Scopus)

Abstract

Respiratory distress syndrome is the commonest respiratory disorder in preterm infants. Although it is well known that preterm birth has a key role, the mechanisms of lung injury have not been fully elucidated. The pathogenesis of this neonatal condition is based on the rapid formation of the oxygen reactive species, which surpasses the detoxification capacity of anti-oxidative defense system. The high reactivity of free radical leads to damage to a variety of molecules and may induce respiratory cell death. There is evidence that the oxidative stress involved in the physiopathology of this disease, is particularly related to oxygen supplementation, mechanical ventilation, inflammation/infection and diabetes. This narrative review summarizes what is known regarding the connection between oxidative stress and respiratory distress syndrome.
Lingua originaleEnglish
pagine (da-a)132-137
Numero di pagine6
RivistaFREE RADICAL BIOLOGY & MEDICINE
Volume142
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology (medical)

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