Role of heme oxygenase-1 (HSP32) and HSP90 in glioblastoma

Francesca Rappa, Daniele Tibullo, Tiziana Bono, Carlo Castruccio Castracani, Roberto Avola, Michelino Di Rosa, Giovanni Li Volti, Pio Maria Furneri

Risultato della ricerca: Articlepeer review

Abstract

Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. The current treatment regimes for glioblastoma demonstrated a low efficiency and offer a poor prognosis. Advancements in conventional treatment strategies have only yielded modest improvements in overall survival. The heat shockproteins, heme oxygenase-1 (HO-1) and Hsp90, serve these pivotal roles in tumor cells and have been identified as effective targets for developing therapeutics. This topic review summarizes the current preclinical and clinical evidences and rationale to define the potential of HO-1 and Hsp90 in GBM progression and chemoresistance.
Lingua originaleEnglish
pagine (da-a)99-107
Numero di pagine9
RivistaEuroMediterranean Biomedical Journal
Volume12
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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