Role of Extracellular Vesicles in Hematological Malignancies

Stefania Raimondo, Giacomo De Leo, Chiara Corrado, Riccardo Alessandro, Riccardo Alessandro, Lavinia Raimondi, Lavinia Raimondi

Risultato della ricerca: Article

15 Citazioni (Scopus)

Abstract

In recent years the role of tumor microenvironment in the progression of hematological malignancies has been widely recognized. Recent studies have focused on how cancer cells communicate within the microenvironment. Among several factors (cytokines, growth factors, and ECM molecules), a key role has been attributed to extracellular vesicles (EV), released from different cell types. EV (microvesicles and exosomes) may affect stroma remodeling, host cell functions, and tumor angiogenesis by inducing gene expression modulation in target cells, thus promoting cancer progression and metastasis. Microvesicles and exosomes can be recovered from the blood and other body fluids of cancer patients and contain and deliver genetic and proteomic contents that reflect the cell of origin, thus constituting a source of new predictive biomarkers involved in cancer development and serving as possible targets for therapies. Moreover, due to their specific cell-tropism and bioavailability, EV can be considered natural vehicles suitable for drug delivery. Here we will discuss the recent advances in the field of EV as actors in hematological cancer progression, pointing out the role of these vesicles in the tumor-host interplay and in their use as biomarkers for hematological malignancies.
Lingua originaleEnglish
pagine (da-a)1-9
Numero di pagine9
RivistaBioMed Research International
Volume2015
Stato di pubblicazionePublished - 2015

Fingerprint

Hematologic Neoplasms
Tumors
Biomarkers
Military electronic countermeasures
Neoplasms
Exosomes
Body fluids
Drug delivery
Gene expression
Intercellular Signaling Peptides and Proteins
Blood
Cells
Modulation
Cytokines
Molecules
Tropism
Tumor Microenvironment
Body Fluids
Extracellular Vesicles
Proteomics

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cita questo

Role of Extracellular Vesicles in Hematological Malignancies. / Raimondo, Stefania; De Leo, Giacomo; Corrado, Chiara; Alessandro, Riccardo; Alessandro, Riccardo; Raimondi, Lavinia; Raimondi, Lavinia.

In: BioMed Research International, Vol. 2015, 2015, pag. 1-9.

Risultato della ricerca: Article

@article{2fb16943ba1a4d6ebc28888d1c537ca7,
title = "Role of Extracellular Vesicles in Hematological Malignancies",
abstract = "In recent years the role of tumor microenvironment in the progression of hematological malignancies has been widely recognized. Recent studies have focused on how cancer cells communicate within the microenvironment. Among several factors (cytokines, growth factors, and ECM molecules), a key role has been attributed to extracellular vesicles (EV), released from different cell types. EV (microvesicles and exosomes) may affect stroma remodeling, host cell functions, and tumor angiogenesis by inducing gene expression modulation in target cells, thus promoting cancer progression and metastasis. Microvesicles and exosomes can be recovered from the blood and other body fluids of cancer patients and contain and deliver genetic and proteomic contents that reflect the cell of origin, thus constituting a source of new predictive biomarkers involved in cancer development and serving as possible targets for therapies. Moreover, due to their specific cell-tropism and bioavailability, EV can be considered natural vehicles suitable for drug delivery. Here we will discuss the recent advances in the field of EV as actors in hematological cancer progression, pointing out the role of these vesicles in the tumor-host interplay and in their use as biomarkers for hematological malignancies.",
keywords = "Biochemistry, Genetics and Molecular Biology (all); Immunology and Microbiology (all)",
author = "Stefania Raimondo and {De Leo}, Giacomo and Chiara Corrado and Riccardo Alessandro and Riccardo Alessandro and Lavinia Raimondi and Lavinia Raimondi",
year = "2015",
language = "English",
volume = "2015",
pages = "1--9",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Role of Extracellular Vesicles in Hematological Malignancies

AU - Raimondo, Stefania

AU - De Leo, Giacomo

AU - Corrado, Chiara

AU - Alessandro, Riccardo

AU - Alessandro, Riccardo

AU - Raimondi, Lavinia

AU - Raimondi, Lavinia

PY - 2015

Y1 - 2015

N2 - In recent years the role of tumor microenvironment in the progression of hematological malignancies has been widely recognized. Recent studies have focused on how cancer cells communicate within the microenvironment. Among several factors (cytokines, growth factors, and ECM molecules), a key role has been attributed to extracellular vesicles (EV), released from different cell types. EV (microvesicles and exosomes) may affect stroma remodeling, host cell functions, and tumor angiogenesis by inducing gene expression modulation in target cells, thus promoting cancer progression and metastasis. Microvesicles and exosomes can be recovered from the blood and other body fluids of cancer patients and contain and deliver genetic and proteomic contents that reflect the cell of origin, thus constituting a source of new predictive biomarkers involved in cancer development and serving as possible targets for therapies. Moreover, due to their specific cell-tropism and bioavailability, EV can be considered natural vehicles suitable for drug delivery. Here we will discuss the recent advances in the field of EV as actors in hematological cancer progression, pointing out the role of these vesicles in the tumor-host interplay and in their use as biomarkers for hematological malignancies.

AB - In recent years the role of tumor microenvironment in the progression of hematological malignancies has been widely recognized. Recent studies have focused on how cancer cells communicate within the microenvironment. Among several factors (cytokines, growth factors, and ECM molecules), a key role has been attributed to extracellular vesicles (EV), released from different cell types. EV (microvesicles and exosomes) may affect stroma remodeling, host cell functions, and tumor angiogenesis by inducing gene expression modulation in target cells, thus promoting cancer progression and metastasis. Microvesicles and exosomes can be recovered from the blood and other body fluids of cancer patients and contain and deliver genetic and proteomic contents that reflect the cell of origin, thus constituting a source of new predictive biomarkers involved in cancer development and serving as possible targets for therapies. Moreover, due to their specific cell-tropism and bioavailability, EV can be considered natural vehicles suitable for drug delivery. Here we will discuss the recent advances in the field of EV as actors in hematological cancer progression, pointing out the role of these vesicles in the tumor-host interplay and in their use as biomarkers for hematological malignancies.

KW - Biochemistry

KW - Genetics and Molecular Biology (all); Immunology and Microbiology (all)

UR - http://hdl.handle.net/10447/155850

UR - http://www.hindawi.com/journals/biomed/

M3 - Article

VL - 2015

SP - 1

EP - 9

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

ER -