Abstract

AAD1. Role of Cytokine Polymorphisms in the Rhinitis-AsthmaEvolutionG. Santini1, L. Scola1, S. La Piana1, P. Di Gangi1, L. Vaccarino1, M. Bova1,C. R. Balistreri1, D. Lio1, G. Di Lorenzo11University of Palermo, Palermo, ItalyBackground: Several epidemiological studies demonstrate that a timelinefrom rhinitis to asthma exists, and that rhinitis is a risk factor for asthma. Inparticular, rhinitis increases the chance of development of asthma byabout three times. In addition to environmental factors, genetic factorsplay an important role in the development of atopic airway diseases. Theaim of this study is to analyse the role of cytokine polymorphism in theevolution of rhinitis-asthma.Methods: A total of 170 allergic patients, 90 affected by rhinitis and 80affected by asthma and 187 controls subjects matched for age and genderwere typed for several single nucleotide polymorphism (SNP) of IL-10(rs1800896), (rs1800871), (rs1800872), IL10RB (rs2834167), IL-6(rs1800795), IL-4 (rs2243248), IL-4R (rs1801275), IL-13 (rs1800925), IL-18 (rs187238), (rs1946518), IL-12 (rs3212227), INFgR (rs1327474) andCD23 (rs2228137) according to our laboratory procedures.Results: The SNPs were in Hardy-Weinberg equilibrium in all threepopulations. None of the analysed SNPs are associated in the evolution ofrhinitis-asthma. Instead, significant differences of genotype and allelicfrequencies between allergic patients and controls were observed in thepolymorphism of IL-6 (p=0.0433 and p=0.0021) IL-13 (p=0.002 andp=0.0006) and IL-18 (p=0.0173 and p=0.0364).Conclusions: The results of our study confirm the already knownassociation of the IL-6, IL-13 and IL-18 polymorphism with allergic airwaydiseases. The possible link between rhinitis and asthma remainsunknown, so additional studies are necessary
Lingua originaleEnglish
Pagine13-13
Numero di pagine1
Stato di pubblicazionePublished - 2014

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