Role of curcumin in idiopathic pulmonary arterial hypertension treatment: A new therapeutic possibility

Salvatore Novo, Antonio Russo, Vincenzo Sucato, Riccardo Di Miceli, Enrico Bronte, Riccardo Di Miceli

Risultato della ricerca: Articlepeer review

17 Citazioni (Scopus)

Abstract

The idiopathic pulmonary arterial hypertension is a complex disease that mainly affects pulmonary arterialcirculation. This undergoes a remodeling with subsequent reduction of flow in the small pulmonaryarteries. Because of this damage an increased vascular resistance gradually develops, and over time it carriesout in heart failure. The inflammatory process is a key element in this condition, mediated by variouscytokines. The inflammatory signal induces activation of NF-jB, and prompts TGF-b-related signalingpathway. Clinical evolution leads to progressive debilitation, greatly affecting the patient quality of life.The actual therapeutic approaches, are few and expensive, and include systemic drugs such as prostanoids,phosphodiesterase inhibitors and antagonists of endothelin-1 (ERBs). Some researchers have longinvestigated the anti-inflammatory effects of curcumin. It shows a role for inactivation ofNF-jB-mediated inflammation. On the basis of these findings we propose a potential role of curcuminand its pharmacologically fit derivatives for treatment of idiopathic pulmonary arterial hypertension.
Lingua originaleEnglish
pagine (da-a)923-926
Numero di pagine4
RivistaMedical Hypotheses
Volume81
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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