The idiopathic pulmonary arterial hypertension is a complex disease that mainly affects pulmonary arterialcirculation. This undergoes a remodeling with subsequent reduction of flow in the small pulmonaryarteries. Because of this damage an increased vascular resistance gradually develops, and over time it carriesout in heart failure. The inflammatory process is a key element in this condition, mediated by variouscytokines. The inflammatory signal induces activation of NF-jB, and prompts TGF-b-related signalingpathway. Clinical evolution leads to progressive debilitation, greatly affecting the patient quality of life.The actual therapeutic approaches, are few and expensive, and include systemic drugs such as prostanoids,phosphodiesterase inhibitors and antagonists of endothelin-1 (ERBs). Some researchers have longinvestigated the anti-inflammatory effects of curcumin. It shows a role for inactivation ofNF-jB-mediated inflammation. On the basis of these findings we propose a potential role of curcuminand its pharmacologically fit derivatives for treatment of idiopathic pulmonary arterial hypertension.
|Numero di pagine||4|
|Stato di pubblicazione||Published - 2013|
All Science Journal Classification (ASJC) codes