Role of apoptosis in autoimmunity

Giorgio Stassi, Matilde Todaro, Giorgio Stassi, Ann Zeuner, Matilde Todaro

Risultato della ricerca: Articlepeer review

33 Citazioni (Scopus)

Abstract

Autoimmune diseases are characterized by the activity of autoreactive lymphocytes that produce antibodies targeting self tissue or organ for destruction. Although the pathogenesis of these diseases is poorly understood, during the past two decades basic research has indicated apoptosis as the pivotal molecular mechanism leading to autoimmunity. Recently cytokines have been invoked in the regulation of the apoptosis-related factors and death receptors in autoimmune target destruction. These research advances have contributed to the identification of mechanisms controlling autoimmunity for defining novel therapeutic strategies.
Lingua originaleEnglish
pagine (da-a)1-11
Numero di pagine11
RivistaJournal of Clinical Immunology
Volume24
Stato di pubblicazionePublished - 2004

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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