Studies have highlighted that the administration of 3,5-diiodo-L-thyronine to rats fed diets rich in lipids induces a decreaseof cholesterol and triglycerides plasma levels and body weightwithout inducing liver steatosis. On the basis of these observationswe carried out some experimental in vivo studies to assessthe effects of multiple high doses of T2 on the pituitary thyroidaxis of rats fed diet rich in lipids. Fifteen male Wistar rats weredivided into three groups of five animals each. The first group(N group) received standard diet, the second group was fedwith a high fat diet (HFD group) while the third group (HFDT2group), was additionally given with T2 intraperitoneally at adose level of 70 g/100 g of body weight three time a weekup to four weeks. At the end of the treatment period blood samplefrom each animal was collected, centrifuged and the resultantserum was stored at -20°C. The serum concentrations ofTSH, T3, T4, ACTH, triglycerides, cholesterol, glucose, alanineaminotransferase, aspartate aminotransferase, alkaline phosphatasewere then determined at various intervals. In addition,liver of rats was examined by histology order to assess the presenceand degree of steatosis. The administration of T2 to ratsfed with a high fat diet suppressed TSH secretion (p=0.013)while no steatosis was observed in the liver of these animals.These preliminary data show that multiple administration ofhigh doses of T2 to rats fed diets rich in lipid inhibits TSH secretionand prevents the onset of liver steatosis in these animals.
|Numero di pagine||1|
|Stato di pubblicazione||Published - 2018|