Robotic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study

Vito Chiantera, Vito Chiantera, Anna Fagotti, Gabriella Ferrandina, Giovanni Scambia, Valerio Gallotta, Giuseppe Vizzielli, Alessandro Lucidi, Barbara Costantini, Carmine Conte, Camilla Nero, Carla Cicero

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Abstract

Study Objective To assess the feasibility of total robotic radical surgery (TRRS) in patients with locally advanced cervical cancer (LACC) who receive chemoradiation therapy (CT/RT). Design A prospective (preplanned) study of a nonrandomized controlled trial (Canadian Task Force classification level 2). Setting Catholic University of the Sacred Hearth, Rome, Italy. Patients Between September 2013 and January 2016, a total of 40 patients with LACC (Fédération Internationale de Gynécologie et d'Obstétrique stage IB2–III) were enrolled in the study. Interventions Robotic radical hysterectomy (RRH) plus pelvic and/or aortic lymphadenectomy was attempted within 6 weeks after CT/RT. The feasibility of TRRS as well as the rate, pattern, and severity of early and late postoperative complications were analyzed. Measurements and Main Results After CT/RT, 29 patients (72.5%) underwent type B2 RRH, and 11 (27.5%) underwent type C1 RRH. Pelvic lymphadenectomy was performed in all cases. TRRS was successful in 39 of 40 cases (feasibility rate = 97.5%). In patients successfully completing TRRS, the median operating time was 185 minutes (range, 100–330 minutes), and the median blood loss was 100 mL (range, 50–300 mL). The median time of hospitalization counted from the first postoperative day was 2 days (range, 1–4 days). No intraoperative complications were recorded. During the observation period (median = 18 months; range, 4–28 months), 9 of 40 (22.5%) experienced postoperative complications, for a total number of 12 complications. As of April 2016, recurrence of disease was documented in 5 cases (12.5%). Conclusion TRRS is feasible in LACC patients administered preoperative CT/RT, providing perioperative outcomes comparable with those registered in early-stage disease, and LACC patients receiving neoadjuvant chemotherapy.
Lingua originaleEnglish
pagine (da-a)133-139
Numero di pagine7
RivistaJournal of Minimally Invasive Gynecology
Volume24
Stato di pubblicazionePublished - 2017

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Robotics
Hysterectomy
Uterine Cervical Neoplasms
Lymph Node Excision
Intraoperative Complications
Advisory Committees
Italy
Hospitalization
Observation
Prospective Studies
Recurrence
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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Robotic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study. / Chiantera, Vito; Chiantera, Vito; Fagotti, Anna; Ferrandina, Gabriella; Scambia, Giovanni; Gallotta, Valerio; Vizzielli, Giuseppe; Lucidi, Alessandro; Costantini, Barbara; Conte, Carmine; Nero, Camilla; Cicero, Carla.

In: Journal of Minimally Invasive Gynecology, Vol. 24, 2017, pag. 133-139.

Risultato della ricerca: Article

Chiantera, V, Chiantera, V, Fagotti, A, Ferrandina, G, Scambia, G, Gallotta, V, Vizzielli, G, Lucidi, A, Costantini, B, Conte, C, Nero, C & Cicero, C 2017, 'Robotic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study', Journal of Minimally Invasive Gynecology, vol. 24, pagg. 133-139.
Chiantera, Vito ; Chiantera, Vito ; Fagotti, Anna ; Ferrandina, Gabriella ; Scambia, Giovanni ; Gallotta, Valerio ; Vizzielli, Giuseppe ; Lucidi, Alessandro ; Costantini, Barbara ; Conte, Carmine ; Nero, Camilla ; Cicero, Carla. / Robotic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study. In: Journal of Minimally Invasive Gynecology. 2017 ; Vol. 24. pagg. 133-139.
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title = "Robotic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study",
abstract = "Study Objective To assess the feasibility of total robotic radical surgery (TRRS) in patients with locally advanced cervical cancer (LACC) who receive chemoradiation therapy (CT/RT). Design A prospective (preplanned) study of a nonrandomized controlled trial (Canadian Task Force classification level 2). Setting Catholic University of the Sacred Hearth, Rome, Italy. Patients Between September 2013 and January 2016, a total of 40 patients with LACC (F{\'e}d{\'e}ration Internationale de Gyn{\'e}cologie et d'Obst{\'e}trique stage IB2–III) were enrolled in the study. Interventions Robotic radical hysterectomy (RRH) plus pelvic and/or aortic lymphadenectomy was attempted within 6 weeks after CT/RT. The feasibility of TRRS as well as the rate, pattern, and severity of early and late postoperative complications were analyzed. Measurements and Main Results After CT/RT, 29 patients (72.5{\%}) underwent type B2 RRH, and 11 (27.5{\%}) underwent type C1 RRH. Pelvic lymphadenectomy was performed in all cases. TRRS was successful in 39 of 40 cases (feasibility rate = 97.5{\%}). In patients successfully completing TRRS, the median operating time was 185 minutes (range, 100–330 minutes), and the median blood loss was 100 mL (range, 50–300 mL). The median time of hospitalization counted from the first postoperative day was 2 days (range, 1–4 days). No intraoperative complications were recorded. During the observation period (median = 18 months; range, 4–28 months), 9 of 40 (22.5{\%}) experienced postoperative complications, for a total number of 12 complications. As of April 2016, recurrence of disease was documented in 5 cases (12.5{\%}). Conclusion TRRS is feasible in LACC patients administered preoperative CT/RT, providing perioperative outcomes comparable with those registered in early-stage disease, and LACC patients receiving neoadjuvant chemotherapy.",
author = "Vito Chiantera and Vito Chiantera and Anna Fagotti and Gabriella Ferrandina and Giovanni Scambia and Valerio Gallotta and Giuseppe Vizzielli and Alessandro Lucidi and Barbara Costantini and Carmine Conte and Camilla Nero and Carla Cicero",
year = "2017",
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journal = "Journal of Minimally Invasive Gynecology",
issn = "1553-4650",
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TY - JOUR

T1 - Robotic Radical Hysterectomy After Concomitant Chemoradiation in Locally Advanced Cervical Cancer: A Prospective Phase II Study

AU - Chiantera, Vito

AU - Chiantera, Vito

AU - Fagotti, Anna

AU - Ferrandina, Gabriella

AU - Scambia, Giovanni

AU - Gallotta, Valerio

AU - Vizzielli, Giuseppe

AU - Lucidi, Alessandro

AU - Costantini, Barbara

AU - Conte, Carmine

AU - Nero, Camilla

AU - Cicero, Carla

PY - 2017

Y1 - 2017

N2 - Study Objective To assess the feasibility of total robotic radical surgery (TRRS) in patients with locally advanced cervical cancer (LACC) who receive chemoradiation therapy (CT/RT). Design A prospective (preplanned) study of a nonrandomized controlled trial (Canadian Task Force classification level 2). Setting Catholic University of the Sacred Hearth, Rome, Italy. Patients Between September 2013 and January 2016, a total of 40 patients with LACC (Fédération Internationale de Gynécologie et d'Obstétrique stage IB2–III) were enrolled in the study. Interventions Robotic radical hysterectomy (RRH) plus pelvic and/or aortic lymphadenectomy was attempted within 6 weeks after CT/RT. The feasibility of TRRS as well as the rate, pattern, and severity of early and late postoperative complications were analyzed. Measurements and Main Results After CT/RT, 29 patients (72.5%) underwent type B2 RRH, and 11 (27.5%) underwent type C1 RRH. Pelvic lymphadenectomy was performed in all cases. TRRS was successful in 39 of 40 cases (feasibility rate = 97.5%). In patients successfully completing TRRS, the median operating time was 185 minutes (range, 100–330 minutes), and the median blood loss was 100 mL (range, 50–300 mL). The median time of hospitalization counted from the first postoperative day was 2 days (range, 1–4 days). No intraoperative complications were recorded. During the observation period (median = 18 months; range, 4–28 months), 9 of 40 (22.5%) experienced postoperative complications, for a total number of 12 complications. As of April 2016, recurrence of disease was documented in 5 cases (12.5%). Conclusion TRRS is feasible in LACC patients administered preoperative CT/RT, providing perioperative outcomes comparable with those registered in early-stage disease, and LACC patients receiving neoadjuvant chemotherapy.

AB - Study Objective To assess the feasibility of total robotic radical surgery (TRRS) in patients with locally advanced cervical cancer (LACC) who receive chemoradiation therapy (CT/RT). Design A prospective (preplanned) study of a nonrandomized controlled trial (Canadian Task Force classification level 2). Setting Catholic University of the Sacred Hearth, Rome, Italy. Patients Between September 2013 and January 2016, a total of 40 patients with LACC (Fédération Internationale de Gynécologie et d'Obstétrique stage IB2–III) were enrolled in the study. Interventions Robotic radical hysterectomy (RRH) plus pelvic and/or aortic lymphadenectomy was attempted within 6 weeks after CT/RT. The feasibility of TRRS as well as the rate, pattern, and severity of early and late postoperative complications were analyzed. Measurements and Main Results After CT/RT, 29 patients (72.5%) underwent type B2 RRH, and 11 (27.5%) underwent type C1 RRH. Pelvic lymphadenectomy was performed in all cases. TRRS was successful in 39 of 40 cases (feasibility rate = 97.5%). In patients successfully completing TRRS, the median operating time was 185 minutes (range, 100–330 minutes), and the median blood loss was 100 mL (range, 50–300 mL). The median time of hospitalization counted from the first postoperative day was 2 days (range, 1–4 days). No intraoperative complications were recorded. During the observation period (median = 18 months; range, 4–28 months), 9 of 40 (22.5%) experienced postoperative complications, for a total number of 12 complications. As of April 2016, recurrence of disease was documented in 5 cases (12.5%). Conclusion TRRS is feasible in LACC patients administered preoperative CT/RT, providing perioperative outcomes comparable with those registered in early-stage disease, and LACC patients receiving neoadjuvant chemotherapy.

UR - http://hdl.handle.net/10447/232920

UR - http://www.elsevier.com/wps/find/journaldescription.cws_home/704371/description#description

M3 - Article

VL - 24

SP - 133

EP - 139

JO - Journal of Minimally Invasive Gynecology

JF - Journal of Minimally Invasive Gynecology

SN - 1553-4650

ER -