Road Traffic Pollution and Childhood Leukemia: A Nationwide Case-control Study in Italy.

Maria Valeria Torregrossa, Daniela Ferrante, Stefania Varotto, Alessandro Polichetti, Luigi Bisanti, Vittorio Bocchini, Claudia Galassi, Gigliola De Nichilo, Manuela Chiavarini, Chiara Badaloni, Francesco Forastiere, Pierluigi Cocco, Serena Risica, Cristina Nuccetelli, Alessandra Ranucci, Gian Luca Desalvo, Daniele Monetti, Paola Michelozzi, Erni Guarino, Rosaria Maria ValentiMarina Cuttini, Cristina Nuccetelli, Alessandra Greco Veneto, Lorenzo Gafà, Francesco Forastiere, Alessandro Polichetti, Gino Schilirò, Andrea Farioli, Lucia Miligi, Gabriella Bernini, Pia Massaglia, Rosaria Maria Valenti, Carmelo Rizzari, Daniele Monetti, Lorenzo Gafà, Lorenzo Gafà, Francesco Forastiere, Gino Schilirò, Paola Mosciatti, Veronica Casotto, Giulia Cesaroni, Ursula Kirchmayer, Franco Pannelli, Santina Cannizzaro, Pierfranco Biddau, Pia Massaglia, Francesco Bochicchio, Roberto Targhetta, Alessandro Pulsoni, Egidio Celentano, Giorgio Assennato, Marina Cuttini, Giuseppe Sampietro, Carmelo Rizzari, Alberto Salvan, Roberto Rondelli, Paola Zambon, Vincenzo Poggi, Susanna Lagorio, Gabriella Bernini, Stefano Mattioli, Corrado Magnani, Rosaria Maria Valenti, Liliana Minelli, Andrea Pession, Lia Lidia Luzzatto, Giuseppe Masera, Stefano Parodi, Riccardo Haupt, Maurizio Aricò, Franco Locatelli, Alessandra Benvenuti, Domenico Franco Merlo

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

The association of childhood leukemia with traffic pollution was considered in a number of studies from 1989 onwards, with results not entirely consistent and little information regarding subtypes.AIM OF THE STUDY:We used the data of the Italian SETIL case-control on childhood leukemia to explore the risk by leukemia subtypes associated to exposure to vehicular traffic.METHODS:We included in the analyses 648 cases of childhood leukemia (565 Acute lymphoblastic-ALL and 80 Acute non lymphoblastic-AnLL) and 980 controls. Information on traffic exposure was collected from questionnaire interviews and from the geocoding of house addresses, for all periods of life of the children.RESULTS:We observed an increase in risk for AnLL, and at a lower extent for ALL, with indicators of exposure to traffic pollutants. In particular, the risk was associated to the report of closeness of the house to traffic lights and to the passage of trucks (OR: 1.76; 95% CI 1.03-3.01 for ALL and 6.35; 95% CI 2.59-15.6 for AnLL). The association was shown also in the analyses limited to AML and in the stratified analyses and in respect to the house in different period of life.CONCLUSIONS:Results from the SETIL study provide some support to the association of traffic related exposure and risk for AnLL, but at a lesser extent for ALL. Our conclusion highlights the need for leukemia type specific analyses in future studies. Results support the need of controlling exposure from traffic pollution, even if knowledge is not complete.
Lingua originaleEnglish
pagine (da-a)694-705
Numero di pagine12
RivistaArchives of Medical Research
Volume47
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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