TY - JOUR
T1 - Risk of childhood leukaemia and non-Hodgkin's lymphoma after parental occupational exposure to solvents and other agents: The SETIL Study
AU - Torregrossa, Maria Valeria
AU - Polichetti, Alessandro
AU - Bisanti, Luigi
AU - Cocco, Pierluigi
AU - Risica, Serena
AU - Ranucci, Alessandra
AU - Miligi, Lucia
AU - Torregrossa, Valeria
AU - Torregrossa, Valeria
AU - Mosciatti, Paola
AU - Kirchmayer, Ursula
AU - Cannizzaro, Santina
AU - Celentano, Egidio
AU - Assennato, Giorgio
AU - Tozzi, Giulio Andrea
AU - Cuttini, Marina
AU - Salvan, Alberto
AU - Rondelli, Roberto
AU - Zambon, Paola
AU - Lagorio, Susanna
AU - Mattioli, Stefano
AU - Magnani, Corrado
AU - Minelli, Liliana
AU - Haupt, Riccardo
AU - Benvenuti, Alessandra
AU - Legittimo, Patrizia
AU - Merlo, Domenico Franco
PY - 2013
Y1 - 2013
N2 - Aim In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. Methods All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. Results 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.4) and mineral oils (OR 1.7). Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2). Conclusions We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts.
AB - Aim In the context of the Italian Multicentric Epidemiological Study on Risk Factors for Childhood Leukaemia and Non-Hodgkin's Lymphoma (SETIL), the risk of childhood cancer was investigated in relation to parental occupational exposures. Methods All cases of childhood leukaemia and non-Hodgkin's lymphoma (NHL) in children aged 0-10 years were identified. Controls were chosen at random from the local population in each region. Parents were interviewed using a structured questionnaire. The collected data were blindly reviewed by expert industrial hygienists in order to estimate exposure to a list of agents. Statistical analyses were performed for each agent using unconditional multivariable logistic regression models, taking into account timing of exposure. Results 683 cases of acute childhood leukaemia, 97 cases of NHL and 1044 controls were identified. Increased risk of childhood leukaemia was found for maternal exposure to aliphatic (OR 4.3) or aromatic hydrocarbons (OR 3.8) in the preconception period, and for paternal exposure to diesel exhaust (OR 1.4), lead exposure (OR 1.4) and mineral oils (OR 1.7). Risk of NHL appeared to be related to paternal exposure to oxygenated solvents (OR 2.5) and petrol exhaust (OR 2.2). Conclusions We found increased risk for childhood leukaemia associated with maternal occupational exposure to aromatic and aliphatic hydrocarbons, particularly in the preconception period; increased risks were also observed for paternal exposure to diesel exhaust fumes, mineral oils and lead. The risk of NHL appeared to be related to paternal exposure to oxygenated solvent and petrol exhausts.
KW - Adolescent; Age Distribution; Case-Control Studies; Chemical Industry; Child; Child
KW - Environmental and Occupational Health
KW - Non-Hodgkin; Male; Maternal Exposure; Multivariate Analysis; Occupational Exposure; Paternal Exposure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment; Sex Distribution; Solvents; Survival Anal
KW - Preschool; Epidemiologic Studies; Female; Hazardous Substances; Humans; Incidence; Italy; Logistic Models; Lymphoma
KW - Adolescent; Age Distribution; Case-Control Studies; Chemical Industry; Child; Child
KW - Environmental and Occupational Health
KW - Non-Hodgkin; Male; Maternal Exposure; Multivariate Analysis; Occupational Exposure; Paternal Exposure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment; Sex Distribution; Solvents; Survival Anal
KW - Preschool; Epidemiologic Studies; Female; Hazardous Substances; Humans; Incidence; Italy; Logistic Models; Lymphoma
UR - http://hdl.handle.net/10447/147216
UR - http://oem.bmj.com/content/70/9/648.full.pdf+html
M3 - Article
VL - 70
SP - 648
EP - 655
JO - Occupational and Environmental Medicine
JF - Occupational and Environmental Medicine
SN - 1351-0711
ER -