Risk of cardiovascular disease morbidity and mortality in frail and pre-frail older adults: Results from a meta-analysis and exploratory meta-regression analysis

Nicola Veronese, Enzo Manzato, Julien Dumurgier, Tamara Harris, Virgilio Garcia Moreira, Fabrizio D'Ascenzo, Nicola Veronese, Valeria Scotti, Giorgio Quadri, Claudio Luchini, Alessandro Polidoro, Timo Strandberg, Monika Eicholzer, Luigi Fontana, Stefania Maggi, Brendon Stubbs, Marco Solmi, Sabine Rohrmann, Helene Amieva, Christoph U. CorrellAlexis Elbaz, Giuseppe Sergi, Peter Manu, Christophe Tzourio, Claudio Moretti, Juan Sanchis, Roberto Alves Lourenço, Emanuele Cereda

Risultato della ricerca: Articlepeer review

74 Citazioni (Scopus)


Frailty is common and associated with poorer outcomes in the elderly, but its role as potential cardiovascular disease (CVD) risk factor requires clarification. We thus aimed to meta-analytically evaluate the evidence of frailty and pre-frailty as risk factors for CVD. Two reviewers selected all studies comparing data about CVD prevalence or incidence rates between frail/pre-frail vs. robust. The association between frailty status and CVD in cross-sectional studies was explored by calculating and pooling crude and adjusted odds ratios (ORs) ±95% confidence intervals (CIs); the data from longitudinal studies were pooled using the adjusted hazard ratios (HRs). Eighteen cohorts with a total of 31,343 participants were meta-analyzed. Using estimates from 10 cross-sectional cohorts, both frailty and pre-frailty were associated with higher odds of CVD than robust participants. Longitudinal data were obtained from 6 prospective cohort studies. After a median follow-up of 4.4 years, we identified an increased risk for faster onset of any-type CVD in the frail (HR = 1.70 [95%CI, 1.18–2.45]; I2 = 66%) and pre-frail (HR = 1.23 [95%CI, 1.07–1.36]; I2 = 67%) vs. robust groups. Similar results were apparent for time to CVD mortality in the frail and pre-frail groups. In conclusion, frailty and pre-frailty constitute addressable and independent risk factors for CVD in older adults. © 2017 Elsevier B.V.
Lingua originaleEnglish
pagine (da-a)63-73
Numero di pagine11
RivistaAgeing Research Reviews
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biochemistry
  • Ageing
  • Molecular Biology
  • Neurology

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