Risk factors for resurgery in men with artificial urinary sphincter: Role of urethral strictures

Alchiede Simonato, Fabio Gallo, Andrea Benelli, Guglielmo Mantica, Paolo Traverso, Davide Becco, Aldo Franco De Rose

Risultato della ricerca: Article

Abstract

Objective: The aims of the present study were to evaluate the outcome of implantation of an artificial urinary sphincter (AUS) in male patients with iatrogenic urinary incontinence and to analyse possible risk factors for resurgery, with particular focus on the effects of posterior urethral strictures (US). Methods: The outcomes of AUS implantation surgeries performed by 2 surgeons on consecutive patients between January 1999 and 2015 were evaluated retrospectively. Univariate analysis with Cox proportional hazard regression was used to assess correlations between resurgery (explantation or substitution of the urethral cuff) and risk factors. Hazard ratios (HR) associated with AUS survival and 95% confidence intervals (CI) were calculated and Kaplan-Meier were constructed. Patients who underwent resurgery for mechanical failure were excluded from the study. Results: In all, 73 male patients were monitored for a maximum of 190months (median follow-up duration 36months). The risk of resurgery was 3.75-fold greater in patients with than without stenosis (HR 3.75; 95% CI 1.47-9.59). In addition, Kaplan-Meier survival curves showed a significantly shorter AUS survival time in patients with than without stenosis treatment. Conclusions: Prior treatment for US increases the relative risk of AUS failure. Despite not being an absolute contraindication for AUS implantation, we suggest that patients with previous treatment for US are informed of potential risks.
Lingua originaleEnglish
pagine (da-a)O16-O20
Numero di pagine5
RivistaLUTS
Volume11
Stato di pubblicazionePublished - 2019

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Artificial Urinary Sphincter
Urethral Stricture
Pathologic Constriction
Confidence Intervals
Survival
Kaplan-Meier Estimate
Urinary Incontinence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Neurology
  • Urology

Cita questo

Simonato, A., Gallo, F., Benelli, A., Mantica, G., Traverso, P., Becco, D., & De Rose, A. F. (2019). Risk factors for resurgery in men with artificial urinary sphincter: Role of urethral strictures. LUTS, 11, O16-O20.

Risk factors for resurgery in men with artificial urinary sphincter: Role of urethral strictures. / Simonato, Alchiede; Gallo, Fabio; Benelli, Andrea; Mantica, Guglielmo; Traverso, Paolo; Becco, Davide; De Rose, Aldo Franco.

In: LUTS, Vol. 11, 2019, pag. O16-O20.

Risultato della ricerca: Article

Simonato, A, Gallo, F, Benelli, A, Mantica, G, Traverso, P, Becco, D & De Rose, AF 2019, 'Risk factors for resurgery in men with artificial urinary sphincter: Role of urethral strictures', LUTS, vol. 11, pagg. O16-O20.
Simonato A, Gallo F, Benelli A, Mantica G, Traverso P, Becco D e altri. Risk factors for resurgery in men with artificial urinary sphincter: Role of urethral strictures. LUTS. 2019;11:O16-O20.
Simonato, Alchiede ; Gallo, Fabio ; Benelli, Andrea ; Mantica, Guglielmo ; Traverso, Paolo ; Becco, Davide ; De Rose, Aldo Franco. / Risk factors for resurgery in men with artificial urinary sphincter: Role of urethral strictures. In: LUTS. 2019 ; Vol. 11. pagg. O16-O20.
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title = "Risk factors for resurgery in men with artificial urinary sphincter: Role of urethral strictures",
abstract = "Objective: The aims of the present study were to evaluate the outcome of implantation of an artificial urinary sphincter (AUS) in male patients with iatrogenic urinary incontinence and to analyse possible risk factors for resurgery, with particular focus on the effects of posterior urethral strictures (US). Methods: The outcomes of AUS implantation surgeries performed by 2 surgeons on consecutive patients between January 1999 and 2015 were evaluated retrospectively. Univariate analysis with Cox proportional hazard regression was used to assess correlations between resurgery (explantation or substitution of the urethral cuff) and risk factors. Hazard ratios (HR) associated with AUS survival and 95{\%} confidence intervals (CI) were calculated and Kaplan-Meier were constructed. Patients who underwent resurgery for mechanical failure were excluded from the study. Results: In all, 73 male patients were monitored for a maximum of 190months (median follow-up duration 36months). The risk of resurgery was 3.75-fold greater in patients with than without stenosis (HR 3.75; 95{\%} CI 1.47-9.59). In addition, Kaplan-Meier survival curves showed a significantly shorter AUS survival time in patients with than without stenosis treatment. Conclusions: Prior treatment for US increases the relative risk of AUS failure. Despite not being an absolute contraindication for AUS implantation, we suggest that patients with previous treatment for US are informed of potential risks.",
author = "Alchiede Simonato and Fabio Gallo and Andrea Benelli and Guglielmo Mantica and Paolo Traverso and Davide Becco and {De Rose}, {Aldo Franco}",
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T1 - Risk factors for resurgery in men with artificial urinary sphincter: Role of urethral strictures

AU - Simonato, Alchiede

AU - Gallo, Fabio

AU - Benelli, Andrea

AU - Mantica, Guglielmo

AU - Traverso, Paolo

AU - Becco, Davide

AU - De Rose, Aldo Franco

PY - 2019

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N2 - Objective: The aims of the present study were to evaluate the outcome of implantation of an artificial urinary sphincter (AUS) in male patients with iatrogenic urinary incontinence and to analyse possible risk factors for resurgery, with particular focus on the effects of posterior urethral strictures (US). Methods: The outcomes of AUS implantation surgeries performed by 2 surgeons on consecutive patients between January 1999 and 2015 were evaluated retrospectively. Univariate analysis with Cox proportional hazard regression was used to assess correlations between resurgery (explantation or substitution of the urethral cuff) and risk factors. Hazard ratios (HR) associated with AUS survival and 95% confidence intervals (CI) were calculated and Kaplan-Meier were constructed. Patients who underwent resurgery for mechanical failure were excluded from the study. Results: In all, 73 male patients were monitored for a maximum of 190months (median follow-up duration 36months). The risk of resurgery was 3.75-fold greater in patients with than without stenosis (HR 3.75; 95% CI 1.47-9.59). In addition, Kaplan-Meier survival curves showed a significantly shorter AUS survival time in patients with than without stenosis treatment. Conclusions: Prior treatment for US increases the relative risk of AUS failure. Despite not being an absolute contraindication for AUS implantation, we suggest that patients with previous treatment for US are informed of potential risks.

AB - Objective: The aims of the present study were to evaluate the outcome of implantation of an artificial urinary sphincter (AUS) in male patients with iatrogenic urinary incontinence and to analyse possible risk factors for resurgery, with particular focus on the effects of posterior urethral strictures (US). Methods: The outcomes of AUS implantation surgeries performed by 2 surgeons on consecutive patients between January 1999 and 2015 were evaluated retrospectively. Univariate analysis with Cox proportional hazard regression was used to assess correlations between resurgery (explantation or substitution of the urethral cuff) and risk factors. Hazard ratios (HR) associated with AUS survival and 95% confidence intervals (CI) were calculated and Kaplan-Meier were constructed. Patients who underwent resurgery for mechanical failure were excluded from the study. Results: In all, 73 male patients were monitored for a maximum of 190months (median follow-up duration 36months). The risk of resurgery was 3.75-fold greater in patients with than without stenosis (HR 3.75; 95% CI 1.47-9.59). In addition, Kaplan-Meier survival curves showed a significantly shorter AUS survival time in patients with than without stenosis treatment. Conclusions: Prior treatment for US increases the relative risk of AUS failure. Despite not being an absolute contraindication for AUS implantation, we suggest that patients with previous treatment for US are informed of potential risks.

UR - http://hdl.handle.net/10447/352446

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ER -