Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy.

Vito Di Marco, Stroffolini, Carlo Ferrari, Teresa Santantonio, Fausto Ancarani, Francavilla, Giuseppe Cariti, Medda, Sergio Babudieri, Gaetano Scotto, Mario Toti, Marco Massari, Fabris, Antonucci, Giuseppe Pastore

Risultato della ricerca: Article

92 Citazioni (Scopus)

Abstract

Background. The epidemiology of acute hepatitis C has changed during the past decade in Western countries. Acute HCV infection has a high rate of chronicity, but it is unclear when patients with acute infection should be treated.Methods. To evaluate current sources of hepatitis C virus (HCV) transmission in Italy and to assess the rate of and factors associated with chronic infection, we enrolled 214 consecutive patients with newly acquired hepatitis C during 1999-2004. The patients were from 12 health care centers throughout the country, and they were followed up for a mean (+/- SD) period of months. Biochemical liver tests were performed, and HCV RNA levels 14 +/- 15.8 were monitored.Results. A total of 146 patients (68%) had symptomatic disease. The most common risk factors for acquiring hepatitis C that were reported were intravenous drug use and medical procedures. The proportion of subjects with spontaneous resolution of infection was 36%. The average timespan from disease onset to HCV RNA clearance was 71 days (range, 27-173 days). In fact, 58 (80%) of 73 patients with self-limiting hepatitis experienced HCV RNA clearance within 3 months of disease onset. Multiple logistic regression analyses showed that none of the variables considered (including asymptomatic disease) were associated with increased risk of developing chronic hepatitis C.Conclusions. These findings underscore the importance of medical procedures as risk factors in the current spread of HCV infection in Italy. Because nearly all patients with acute, self-limiting hepatitis C-both symptomatic and asymptomatic-have spontaneous viral clearance within 3 months of disease onset, it seems reasonable to start treatment after this time period ends to avoid costly and useless treatment
Lingua originaleEnglish
pagine (da-a)1154-1159
Numero di pagine6
RivistaClinical Infectious Diseases
Volume43
Stato di pubblicazionePublished - 2006

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Hepatitis C
Hepacivirus
Italy
Virus Diseases
RNA
Infection
Asymptomatic Diseases
Chronic Hepatitis C
Hepatitis
Epidemiology
Logistic Models
Regression Analysis
Delivery of Health Care
Liver
Therapeutics
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cita questo

Di Marco, V., Stroffolini, Ferrari, C., Santantonio, T., Ancarani, F., Francavilla, ... Pastore, G. (2006). Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy. Clinical Infectious Diseases, 43, 1154-1159.

Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy. / Di Marco, Vito; Stroffolini; Ferrari, Carlo; Santantonio, Teresa; Ancarani, Fausto; Francavilla; Cariti, Giuseppe; Medda; Babudieri, Sergio; Scotto, Gaetano; Toti, Mario; Massari, Marco; Fabris; Antonucci; Pastore, Giuseppe.

In: Clinical Infectious Diseases, Vol. 43, 2006, pag. 1154-1159.

Risultato della ricerca: Article

Di Marco, V, Stroffolini, Ferrari, C, Santantonio, T, Ancarani, F, Francavilla, Cariti, G, Medda, Babudieri, S, Scotto, G, Toti, M, Massari, M, Fabris, Antonucci & Pastore, G 2006, 'Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy.', Clinical Infectious Diseases, vol. 43, pagg. 1154-1159.
Di Marco, Vito ; Stroffolini ; Ferrari, Carlo ; Santantonio, Teresa ; Ancarani, Fausto ; Francavilla ; Cariti, Giuseppe ; Medda ; Babudieri, Sergio ; Scotto, Gaetano ; Toti, Mario ; Massari, Marco ; Fabris ; Antonucci ; Pastore, Giuseppe. / Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy. In: Clinical Infectious Diseases. 2006 ; Vol. 43. pagg. 1154-1159.
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title = "Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy.",
abstract = "Background. The epidemiology of acute hepatitis C has changed during the past decade in Western countries. Acute HCV infection has a high rate of chronicity, but it is unclear when patients with acute infection should be treated.Methods. To evaluate current sources of hepatitis C virus (HCV) transmission in Italy and to assess the rate of and factors associated with chronic infection, we enrolled 214 consecutive patients with newly acquired hepatitis C during 1999-2004. The patients were from 12 health care centers throughout the country, and they were followed up for a mean (+/- SD) period of months. Biochemical liver tests were performed, and HCV RNA levels 14 +/- 15.8 were monitored.Results. A total of 146 patients (68{\%}) had symptomatic disease. The most common risk factors for acquiring hepatitis C that were reported were intravenous drug use and medical procedures. The proportion of subjects with spontaneous resolution of infection was 36{\%}. The average timespan from disease onset to HCV RNA clearance was 71 days (range, 27-173 days). In fact, 58 (80{\%}) of 73 patients with self-limiting hepatitis experienced HCV RNA clearance within 3 months of disease onset. Multiple logistic regression analyses showed that none of the variables considered (including asymptomatic disease) were associated with increased risk of developing chronic hepatitis C.Conclusions. These findings underscore the importance of medical procedures as risk factors in the current spread of HCV infection in Italy. Because nearly all patients with acute, self-limiting hepatitis C-both symptomatic and asymptomatic-have spontaneous viral clearance within 3 months of disease onset, it seems reasonable to start treatment after this time period ends to avoid costly and useless treatment",
author = "{Di Marco}, Vito and Stroffolini and Carlo Ferrari and Teresa Santantonio and Fausto Ancarani and Francavilla and Giuseppe Cariti and Medda and Sergio Babudieri and Gaetano Scotto and Mario Toti and Marco Massari and Fabris and Antonucci and Giuseppe Pastore",
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T1 - Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy.

AU - Di Marco, Vito

AU - Stroffolini, null

AU - Ferrari, Carlo

AU - Santantonio, Teresa

AU - Ancarani, Fausto

AU - Francavilla, null

AU - Cariti, Giuseppe

AU - Medda, null

AU - Babudieri, Sergio

AU - Scotto, Gaetano

AU - Toti, Mario

AU - Massari, Marco

AU - Fabris, null

AU - Antonucci, null

AU - Pastore, Giuseppe

PY - 2006

Y1 - 2006

N2 - Background. The epidemiology of acute hepatitis C has changed during the past decade in Western countries. Acute HCV infection has a high rate of chronicity, but it is unclear when patients with acute infection should be treated.Methods. To evaluate current sources of hepatitis C virus (HCV) transmission in Italy and to assess the rate of and factors associated with chronic infection, we enrolled 214 consecutive patients with newly acquired hepatitis C during 1999-2004. The patients were from 12 health care centers throughout the country, and they were followed up for a mean (+/- SD) period of months. Biochemical liver tests were performed, and HCV RNA levels 14 +/- 15.8 were monitored.Results. A total of 146 patients (68%) had symptomatic disease. The most common risk factors for acquiring hepatitis C that were reported were intravenous drug use and medical procedures. The proportion of subjects with spontaneous resolution of infection was 36%. The average timespan from disease onset to HCV RNA clearance was 71 days (range, 27-173 days). In fact, 58 (80%) of 73 patients with self-limiting hepatitis experienced HCV RNA clearance within 3 months of disease onset. Multiple logistic regression analyses showed that none of the variables considered (including asymptomatic disease) were associated with increased risk of developing chronic hepatitis C.Conclusions. These findings underscore the importance of medical procedures as risk factors in the current spread of HCV infection in Italy. Because nearly all patients with acute, self-limiting hepatitis C-both symptomatic and asymptomatic-have spontaneous viral clearance within 3 months of disease onset, it seems reasonable to start treatment after this time period ends to avoid costly and useless treatment

AB - Background. The epidemiology of acute hepatitis C has changed during the past decade in Western countries. Acute HCV infection has a high rate of chronicity, but it is unclear when patients with acute infection should be treated.Methods. To evaluate current sources of hepatitis C virus (HCV) transmission in Italy and to assess the rate of and factors associated with chronic infection, we enrolled 214 consecutive patients with newly acquired hepatitis C during 1999-2004. The patients were from 12 health care centers throughout the country, and they were followed up for a mean (+/- SD) period of months. Biochemical liver tests were performed, and HCV RNA levels 14 +/- 15.8 were monitored.Results. A total of 146 patients (68%) had symptomatic disease. The most common risk factors for acquiring hepatitis C that were reported were intravenous drug use and medical procedures. The proportion of subjects with spontaneous resolution of infection was 36%. The average timespan from disease onset to HCV RNA clearance was 71 days (range, 27-173 days). In fact, 58 (80%) of 73 patients with self-limiting hepatitis experienced HCV RNA clearance within 3 months of disease onset. Multiple logistic regression analyses showed that none of the variables considered (including asymptomatic disease) were associated with increased risk of developing chronic hepatitis C.Conclusions. These findings underscore the importance of medical procedures as risk factors in the current spread of HCV infection in Italy. Because nearly all patients with acute, self-limiting hepatitis C-both symptomatic and asymptomatic-have spontaneous viral clearance within 3 months of disease onset, it seems reasonable to start treatment after this time period ends to avoid costly and useless treatment

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