RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets

Giovanni Perconti, Giorgio Bertolazzi, Serena Bivona, Flavia Contino, Michele Tumminello, Salvatore Feo, Giovanni Perconti, Claudia Coronnello, Patrizia Rubino, Agata Giallongo, Claudia Coronnello

Risultato della ricerca: Article

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line
Lingua originaleEnglish
pagine (da-a)00-00
Numero di pagine13
RivistaBMC Bioinformatics
Volume20
Stato di pubblicazionePublished - 2019

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RNA-Induced Silencing Complex
MicroRNA
RNA
MicroRNAs
Messenger RNA
Chip
Proteins
Protein
Target
Cell
Complex Functions
Processing
Breast Cancer
Template
Small Untranslated RNA
Degradation
RNA Stability
Molecules
Line
Cells

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Applied Mathematics

Cita questo

RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets. / Perconti, Giovanni; Bertolazzi, Giorgio; Bivona, Serena; Contino, Flavia; Tumminello, Michele; Feo, Salvatore; Perconti, Giovanni; Coronnello, Claudia; Rubino, Patrizia; Giallongo, Agata; Coronnello, Claudia.

In: BMC Bioinformatics, Vol. 20, 2019, pag. 00-00.

Risultato della ricerca: Article

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AU - Bertolazzi, Giorgio

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AU - Contino, Flavia

AU - Tumminello, Michele

AU - Feo, Salvatore

AU - Perconti, Giovanni

AU - Coronnello, Claudia

AU - Rubino, Patrizia

AU - Giallongo, Agata

AU - Coronnello, Claudia

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AB - MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line

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