RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets

Flavia Contino; Michele Tumminello; Serena Bivona; Salvatore Feo; Giorgio Bertolazzi; Giovanni Perconti; Claudia Coronnello; Patrizia Rubino; Agata Giallongo

RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets

Flavia Contino, Michele Tumminello, Serena Bivona, Salvatore Feo, Giorgio Bertolazzi, Giovanni Perconti, Claudia Coronnello, Patrizia Rubino, Agata Giallongo

Risultato della ricerca: Article › peer review

4 Citazioni (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line

Lingua originale	English
pagine (da-a)	1-13
Numero di pagine	13
Rivista	BMC Bioinformatics
Volume	20
Stato di pubblicazione	Published - 2019

All Science Journal Classification (ASJC) codes

Structural Biology
Biochemistry
Molecular Biology
Computer Science Applications
Applied Mathematics

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RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets. / Contino, Flavia ; Tumminello, Michele ; Bivona, Serena ; Feo, Salvatore ; Bertolazzi, Giorgio; Perconti, Giovanni; Coronnello, Claudia; Rubino, Patrizia; Giallongo, Agata.

In: BMC Bioinformatics, Vol. 20, 2019, pag. 1-13.

Risultato della ricerca: Article › peer review

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AU - Tumminello, Michele

AU - Bivona, Serena

AU - Feo, Salvatore

AU - Bertolazzi, Giorgio

AU - Perconti, Giovanni

AU - Coronnello, Claudia

AU - Rubino, Patrizia

AU - Giallongo, Agata

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AB - MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line

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