RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets

Flavia Contino, Michele Tumminello, Serena Bivona, Salvatore Feo, Giorgio Bertolazzi, Giovanni Perconti, Claudia Coronnello, Patrizia Rubino, Agata Giallongo

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules mediating the translational repression and degradation of target mRNAs in the cell. Mature miRNAs are used as a template by the RNA-induced silencing complex (RISC) to recognize the complementary mRNAs to be regulated. To discern further RISC functions, we analyzed the activities of two RISC proteins, AGO2 and GW182, in the MCF-7 human breast cancer cell line
Lingua originaleEnglish
pagine (da-a)1-13
Numero di pagine13
RivistaBMC Bioinformatics
Volume20
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Applied Mathematics

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