Abstract

Aims and objectivesTo investigate functional connectivity changes in pathological gamblers (PGs) in comparison to healthy controls (HCs) by means of resting state functional Magnetic Resonance Imaging (RS-fMRI).Methods and materialsThirteen HCs and fourteen PGs were recruited (all right handed males; drugs free; mean age 35.96±9.56). All subjects underwent brain scan using a 1,5T MRI scanner. Activations data of functionally linked brain regions were obtained using a multi-session temporal concatenated Independent Component Analysis (concat-ICA). The resulted components were than matched and compared between groups. Correction for multiple comparisons across space was applied assuming an overall significance of p < 0.05 using permutation testing and threshold-free cluster enhancement.ResultsIn PGs subjects, compared to HCs, we found an increased functional connectivity in several networks including: anterior cingulate cortex, accumbens nucleus, head of the caudate nucleus, middle left temporal gyrus, right insula, right cerebellar hemisphere cortex and cerebellar vermis.ConclusionOur study has showed an hyperconnectivity together with an overactivation of specific regions in PGs. The presence of increased functional connectivity in brain regions involved in the processing of rewards and external stimuli, in the attribution of spatiotemporal characteristics to events significance, and the resulting decision-making process, confirms the neurofunctional basis underlying clinical features of gambling disorder. PGs may therefore exhibit a state reduced triggering threshold to gaming due to a persistent activation of specific functional networks recruited during gambling tasks.
Lingua originaleEnglish
Numero di pagine15
Stato di pubblicazionePublished - 2018

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Reward
Gambling
Magnetic Resonance Imaging
Brain
Cerebellar Cortex
Caudate Nucleus
Gyrus Cinguli
Nucleus Accumbens
Temporal Lobe
Decision Making
Pharmaceutical Preparations

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@conference{d97bfdc4427f47fbaad53709e90c627e,
title = "Reward networks changes in the brain of pathological gamblers: a resting state functional magnetic resonance imaging study",
abstract = "Aims and objectivesTo investigate functional connectivity changes in pathological gamblers (PGs) in comparison to healthy controls (HCs) by means of resting state functional Magnetic Resonance Imaging (RS-fMRI).Methods and materialsThirteen HCs and fourteen PGs were recruited (all right handed males; drugs free; mean age 35.96±9.56). All subjects underwent brain scan using a 1,5T MRI scanner. Activations data of functionally linked brain regions were obtained using a multi-session temporal concatenated Independent Component Analysis (concat-ICA). The resulted components were than matched and compared between groups. Correction for multiple comparisons across space was applied assuming an overall significance of p < 0.05 using permutation testing and threshold-free cluster enhancement.ResultsIn PGs subjects, compared to HCs, we found an increased functional connectivity in several networks including: anterior cingulate cortex, accumbens nucleus, head of the caudate nucleus, middle left temporal gyrus, right insula, right cerebellar hemisphere cortex and cerebellar vermis.ConclusionOur study has showed an hyperconnectivity together with an overactivation of specific regions in PGs. The presence of increased functional connectivity in brain regions involved in the processing of rewards and external stimuli, in the attribution of spatiotemporal characteristics to events significance, and the resulting decision-making process, confirms the neurofunctional basis underlying clinical features of gambling disorder. PGs may therefore exhibit a state reduced triggering threshold to gaming due to a persistent activation of specific functional networks recruited during gambling tasks.",
author = "Cesare Gagliardo and {La Barbera}, Daniele and Tommaso Piccoli and Maurizio Marrale and Roberto Lagalla and Giuseppe Maniaci and Carla Cannizzaro and Giorgio Collura and {La Tona}, Giuseppe",
year = "2018",
language = "English",

}

TY - CONF

T1 - Reward networks changes in the brain of pathological gamblers: a resting state functional magnetic resonance imaging study

AU - Gagliardo, Cesare

AU - La Barbera, Daniele

AU - Piccoli, Tommaso

AU - Marrale, Maurizio

AU - Lagalla, Roberto

AU - Maniaci, Giuseppe

AU - Cannizzaro, Carla

AU - Collura, Giorgio

AU - La Tona, Giuseppe

PY - 2018

Y1 - 2018

N2 - Aims and objectivesTo investigate functional connectivity changes in pathological gamblers (PGs) in comparison to healthy controls (HCs) by means of resting state functional Magnetic Resonance Imaging (RS-fMRI).Methods and materialsThirteen HCs and fourteen PGs were recruited (all right handed males; drugs free; mean age 35.96±9.56). All subjects underwent brain scan using a 1,5T MRI scanner. Activations data of functionally linked brain regions were obtained using a multi-session temporal concatenated Independent Component Analysis (concat-ICA). The resulted components were than matched and compared between groups. Correction for multiple comparisons across space was applied assuming an overall significance of p < 0.05 using permutation testing and threshold-free cluster enhancement.ResultsIn PGs subjects, compared to HCs, we found an increased functional connectivity in several networks including: anterior cingulate cortex, accumbens nucleus, head of the caudate nucleus, middle left temporal gyrus, right insula, right cerebellar hemisphere cortex and cerebellar vermis.ConclusionOur study has showed an hyperconnectivity together with an overactivation of specific regions in PGs. The presence of increased functional connectivity in brain regions involved in the processing of rewards and external stimuli, in the attribution of spatiotemporal characteristics to events significance, and the resulting decision-making process, confirms the neurofunctional basis underlying clinical features of gambling disorder. PGs may therefore exhibit a state reduced triggering threshold to gaming due to a persistent activation of specific functional networks recruited during gambling tasks.

AB - Aims and objectivesTo investigate functional connectivity changes in pathological gamblers (PGs) in comparison to healthy controls (HCs) by means of resting state functional Magnetic Resonance Imaging (RS-fMRI).Methods and materialsThirteen HCs and fourteen PGs were recruited (all right handed males; drugs free; mean age 35.96±9.56). All subjects underwent brain scan using a 1,5T MRI scanner. Activations data of functionally linked brain regions were obtained using a multi-session temporal concatenated Independent Component Analysis (concat-ICA). The resulted components were than matched and compared between groups. Correction for multiple comparisons across space was applied assuming an overall significance of p < 0.05 using permutation testing and threshold-free cluster enhancement.ResultsIn PGs subjects, compared to HCs, we found an increased functional connectivity in several networks including: anterior cingulate cortex, accumbens nucleus, head of the caudate nucleus, middle left temporal gyrus, right insula, right cerebellar hemisphere cortex and cerebellar vermis.ConclusionOur study has showed an hyperconnectivity together with an overactivation of specific regions in PGs. The presence of increased functional connectivity in brain regions involved in the processing of rewards and external stimuli, in the attribution of spatiotemporal characteristics to events significance, and the resulting decision-making process, confirms the neurofunctional basis underlying clinical features of gambling disorder. PGs may therefore exhibit a state reduced triggering threshold to gaming due to a persistent activation of specific functional networks recruited during gambling tasks.

UR - http://hdl.handle.net/10447/303917

M3 - Other

ER -