Reversible effect of magnetic fields on human lymphocyte activation patterns: different sensitivity of naive and memory lymphocyte subsets.

Antonio Lo Casto; Carmela La Mendola; Nadia Rosalia Caccamo; Alfredo Salerno; Sergio Salerno; Marco Pio La Manna

Reversible effect of magnetic fields on human lymphocyte activation patterns: different sensitivity of naive and memory lymphocyte subsets.

Antonio Lo Casto, Carmela La Mendola, Nadia Rosalia Caccamo, Alfredo Salerno, Sergio Salerno, Marco Pio La Manna

Biomedicina, Neuroscienze e Diagnostica avanzata

Risultato della ricerca: Article › peer review

4 Citazioni (Scopus)

Abstract

The aim of this study was to investigate the influence of 50 Hzmagnetic or static magnetic fields of 0.5 mT on subsets of humanCD4+ T cells in terms of cytokine release/content, cellproliferation and intracellular free calcium concentration.CD4+ T cells can be divided into different subsets on the basisof surface marker expression, such as CD45, and T cells can bedivided into naive (CD45RA+) and memory (CD45RA2) cells. Inthis study, the effects of magnetic fields after 24 and 48 h of cellculture were analyzed. We found that the CD4+CD45RA2 Tsubset were more sensitive after 2 h of exposure. Decreases inthe release/content of IFN-c, in cell proliferation and inintracellular free calcium concentrations were observed inexposed CD4+CD45RA2 T cells compared to CD4+CD45RA+T cells. The results suggest that exposure to the magnetic fieldsinduces a delay in the response to stimulants and thatmodifications are rapidly reversible, at least after a shortexposure.

Lingua originale	English
Numero di pagine	7
Rivista	Radiation Research
Volume	2009-10
Stato di pubblicazione	Published - 2009

All Science Journal Classification (ASJC) codes

Biophysics
Radiation
Radiology Nuclear Medicine and imaging

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@article{64ad53c48ca54e518eab45d5b9165adc,

title = "Reversible effect of magnetic fields on human lymphocyte activation patterns: different sensitivity of naive and memory lymphocyte subsets.",

abstract = "The aim of this study was to investigate the influence of 50 Hzmagnetic or static magnetic fields of 0.5 mT on subsets of humanCD4+ T cells in terms of cytokine release/content, cellproliferation and intracellular free calcium concentration.CD4+ T cells can be divided into different subsets on the basisof surface marker expression, such as CD45, and T cells can bedivided into naive (CD45RA+) and memory (CD45RA2) cells. Inthis study, the effects of magnetic fields after 24 and 48 h of cellculture were analyzed. We found that the CD4+CD45RA2 Tsubset were more sensitive after 2 h of exposure. Decreases inthe release/content of IFN-c, in cell proliferation and inintracellular free calcium concentrations were observed inexposed CD4+CD45RA2 T cells compared to CD4+CD45RA+T cells. The results suggest that exposure to the magnetic fieldsinduces a delay in the response to stimulants and thatmodifications are rapidly reversible, at least after a shortexposure.",

keywords = "CD4(+) T cells., static magnetic fields, CD4(+) T cells., static magnetic fields",

author = "{Lo Casto}, Antonio and {La Mendola}, Carmela and Caccamo, {Nadia Rosalia} and Alfredo Salerno and Sergio Salerno and {La Manna}, {Marco Pio}",

year = "2009",

language = "English",

volume = "2009-10",

journal = "Radiation Research",

issn = "0033-7587",

publisher = "Radiation Research Society",

}

TY - JOUR

T1 - Reversible effect of magnetic fields on human lymphocyte activation patterns: different sensitivity of naive and memory lymphocyte subsets.

AU - Lo Casto, Antonio

AU - La Mendola, Carmela

AU - Caccamo, Nadia Rosalia

AU - Salerno, Alfredo

AU - Salerno, Sergio

AU - La Manna, Marco Pio

PY - 2009

Y1 - 2009

N2 - The aim of this study was to investigate the influence of 50 Hzmagnetic or static magnetic fields of 0.5 mT on subsets of humanCD4+ T cells in terms of cytokine release/content, cellproliferation and intracellular free calcium concentration.CD4+ T cells can be divided into different subsets on the basisof surface marker expression, such as CD45, and T cells can bedivided into naive (CD45RA+) and memory (CD45RA2) cells. Inthis study, the effects of magnetic fields after 24 and 48 h of cellculture were analyzed. We found that the CD4+CD45RA2 Tsubset were more sensitive after 2 h of exposure. Decreases inthe release/content of IFN-c, in cell proliferation and inintracellular free calcium concentrations were observed inexposed CD4+CD45RA2 T cells compared to CD4+CD45RA+T cells. The results suggest that exposure to the magnetic fieldsinduces a delay in the response to stimulants and thatmodifications are rapidly reversible, at least after a shortexposure.

AB - The aim of this study was to investigate the influence of 50 Hzmagnetic or static magnetic fields of 0.5 mT on subsets of humanCD4+ T cells in terms of cytokine release/content, cellproliferation and intracellular free calcium concentration.CD4+ T cells can be divided into different subsets on the basisof surface marker expression, such as CD45, and T cells can bedivided into naive (CD45RA+) and memory (CD45RA2) cells. Inthis study, the effects of magnetic fields after 24 and 48 h of cellculture were analyzed. We found that the CD4+CD45RA2 Tsubset were more sensitive after 2 h of exposure. Decreases inthe release/content of IFN-c, in cell proliferation and inintracellular free calcium concentrations were observed inexposed CD4+CD45RA2 T cells compared to CD4+CD45RA+T cells. The results suggest that exposure to the magnetic fieldsinduces a delay in the response to stimulants and thatmodifications are rapidly reversible, at least after a shortexposure.

KW - CD4(+) T cells.

KW - static magnetic fields

KW - CD4(+) T cells.

KW - static magnetic fields

UR - http://hdl.handle.net/10447/44939

M3 - Article

VL - 2009-10

JO - Radiation Research

JF - Radiation Research

SN - 0033-7587

ER -