The aim of this study was to investigate the influence of 50 Hzmagnetic or static magnetic fields of 0.5 mT on subsets of humanCD4+ T cells in terms of cytokine release/content, cellproliferation and intracellular free calcium concentration.CD4+ T cells can be divided into different subsets on the basisof surface marker expression, such as CD45, and T cells can bedivided into naive (CD45RA+) and memory (CD45RA2) cells. Inthis study, the effects of magnetic fields after 24 and 48 h of cellculture were analyzed. We found that the CD4+CD45RA2 Tsubset were more sensitive after 2 h of exposure. Decreases inthe release/content of IFN-c, in cell proliferation and inintracellular free calcium concentrations were observed inexposed CD4+CD45RA2 T cells compared to CD4+CD45RA+T cells. The results suggest that exposure to the magnetic fieldsinduces a delay in the response to stimulants and thatmodifications are rapidly reversible, at least after a shortexposure.
|Numero di pagine||7|
|Stato di pubblicazione||Published - 2009|
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