Reticulocytes in untreated obstructive sleep apnoea.

Maria Rosaria Bonsignore, Loredana Riccobono, Profita, Oreste Marrone, Salvaggio, Bonanno, Maria Gioia, Insalaco

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

Background and Aim. The short, repetitive hypoxaemic episodes observed in obstructive sleep apnoea (OSA) may determine small augmentations in mature red blood cells. It is unknown whether they affect reticulocyte release. This study explored whether the number and degree of maturation of circulating reticulocytes may be altered in OSA, possibly through the effect of erythropoietin. Methods. Fifty male adult patients with suspected OSA, normoxic during wakefulness, were studied. After nocturnal polysomnography, a blood sample was withdrawn for blood cells count, erythropoietin, iron and transferrin determination. Reticulocyte concentration and degree of immaturity [high (H), medium (M), or low (L)] were also determined. Immature reticulocyte fraction (IRF) was calculated as (M+H) percentage of reticulocytes. Results. A wide range of OSA severity was found [apnoea/hypopnoea index (AHI): 44.3±30.4, range 0.3-105; sleep time spent at oxyhaemoglobin saturation <90%: 18.1±22.2%, range 0-81%]. Both reticulocyte count and IRF slightly exceeded the normal range. Patients with a reticulocyte concentration >2% had higher EPO levels (p<0.05), but not worse nocturnal desaturations, than those with values <2%. By contrast, subjects with IRF <15% showed worse desaturations (p<0.05), but similar EPO concentrations, when compared to subjects whose IRF was <10%. At univariate analysis, reticulocyte count correlated to erythropoietin, while IRF to transferrin saturation, BMI and OSA severity. At multiple regression, only lowest nocturnal oxygen saturation remained a significant contributor to IRF (r2 0.223, p<0.05). Conclusions. This data suggests that hypoxaemia due to OSA could influence the release of immature reticulocytes, but this effect is not mediated by erythropoietin.
Lingua originaleEnglish
pagine (da-a)107-113
Numero di pagine7
RivistaMonaldi Archives for Chest Disease
Volume69
Stato di pubblicazionePublished - 2008

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Reticulocytes
Obstructive Sleep Apnea
Erythropoietin
Reticulocyte Count
Transferrin
Oxyhemoglobins
Blood Cell Count
Polysomnography
Wakefulness
Apnea
Sleep
Reference Values
Iron
Erythrocytes
Oxygen

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

Cita questo

Bonsignore, M. R., Riccobono, L., Profita, Marrone, O., Salvaggio, Bonanno, ... Insalaco (2008). Reticulocytes in untreated obstructive sleep apnoea. Monaldi Archives for Chest Disease, 69, 107-113.

Reticulocytes in untreated obstructive sleep apnoea. / Bonsignore, Maria Rosaria; Riccobono, Loredana; Profita; Marrone, Oreste; Salvaggio; Bonanno; Gioia, Maria; Insalaco.

In: Monaldi Archives for Chest Disease, Vol. 69, 2008, pag. 107-113.

Risultato della ricerca: Article

Bonsignore, MR, Riccobono, L, Profita, Marrone, O, Salvaggio, Bonanno, Gioia, M & Insalaco 2008, 'Reticulocytes in untreated obstructive sleep apnoea.', Monaldi Archives for Chest Disease, vol. 69, pagg. 107-113.
Bonsignore MR, Riccobono L, Profita, Marrone O, Salvaggio, Bonanno e altri. Reticulocytes in untreated obstructive sleep apnoea. Monaldi Archives for Chest Disease. 2008;69:107-113.
Bonsignore, Maria Rosaria ; Riccobono, Loredana ; Profita ; Marrone, Oreste ; Salvaggio ; Bonanno ; Gioia, Maria ; Insalaco. / Reticulocytes in untreated obstructive sleep apnoea. In: Monaldi Archives for Chest Disease. 2008 ; Vol. 69. pagg. 107-113.
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title = "Reticulocytes in untreated obstructive sleep apnoea.",
abstract = "Background and Aim. The short, repetitive hypoxaemic episodes observed in obstructive sleep apnoea (OSA) may determine small augmentations in mature red blood cells. It is unknown whether they affect reticulocyte release. This study explored whether the number and degree of maturation of circulating reticulocytes may be altered in OSA, possibly through the effect of erythropoietin. Methods. Fifty male adult patients with suspected OSA, normoxic during wakefulness, were studied. After nocturnal polysomnography, a blood sample was withdrawn for blood cells count, erythropoietin, iron and transferrin determination. Reticulocyte concentration and degree of immaturity [high (H), medium (M), or low (L)] were also determined. Immature reticulocyte fraction (IRF) was calculated as (M+H) percentage of reticulocytes. Results. A wide range of OSA severity was found [apnoea/hypopnoea index (AHI): 44.3±30.4, range 0.3-105; sleep time spent at oxyhaemoglobin saturation <90{\%}: 18.1±22.2{\%}, range 0-81{\%}]. Both reticulocyte count and IRF slightly exceeded the normal range. Patients with a reticulocyte concentration >2{\%} had higher EPO levels (p<0.05), but not worse nocturnal desaturations, than those with values <2{\%}. By contrast, subjects with IRF <15{\%} showed worse desaturations (p<0.05), but similar EPO concentrations, when compared to subjects whose IRF was <10{\%}. At univariate analysis, reticulocyte count correlated to erythropoietin, while IRF to transferrin saturation, BMI and OSA severity. At multiple regression, only lowest nocturnal oxygen saturation remained a significant contributor to IRF (r2 0.223, p<0.05). Conclusions. This data suggests that hypoxaemia due to OSA could influence the release of immature reticulocytes, but this effect is not mediated by erythropoietin.",
keywords = "Haematopoiesis, Nocturnal hypoxemia, Obstructive sleep apnoea, Erythropoietin",
author = "Bonsignore, {Maria Rosaria} and Loredana Riccobono and Profita and Oreste Marrone and Salvaggio and Bonanno and Maria Gioia and Insalaco",
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journal = "Monaldi Archives for Chest Disease",
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TY - JOUR

T1 - Reticulocytes in untreated obstructive sleep apnoea.

AU - Bonsignore, Maria Rosaria

AU - Riccobono, Loredana

AU - Profita, null

AU - Marrone, Oreste

AU - Salvaggio, null

AU - Bonanno, null

AU - Gioia, Maria

AU - Insalaco, null

PY - 2008

Y1 - 2008

N2 - Background and Aim. The short, repetitive hypoxaemic episodes observed in obstructive sleep apnoea (OSA) may determine small augmentations in mature red blood cells. It is unknown whether they affect reticulocyte release. This study explored whether the number and degree of maturation of circulating reticulocytes may be altered in OSA, possibly through the effect of erythropoietin. Methods. Fifty male adult patients with suspected OSA, normoxic during wakefulness, were studied. After nocturnal polysomnography, a blood sample was withdrawn for blood cells count, erythropoietin, iron and transferrin determination. Reticulocyte concentration and degree of immaturity [high (H), medium (M), or low (L)] were also determined. Immature reticulocyte fraction (IRF) was calculated as (M+H) percentage of reticulocytes. Results. A wide range of OSA severity was found [apnoea/hypopnoea index (AHI): 44.3±30.4, range 0.3-105; sleep time spent at oxyhaemoglobin saturation <90%: 18.1±22.2%, range 0-81%]. Both reticulocyte count and IRF slightly exceeded the normal range. Patients with a reticulocyte concentration >2% had higher EPO levels (p<0.05), but not worse nocturnal desaturations, than those with values <2%. By contrast, subjects with IRF <15% showed worse desaturations (p<0.05), but similar EPO concentrations, when compared to subjects whose IRF was <10%. At univariate analysis, reticulocyte count correlated to erythropoietin, while IRF to transferrin saturation, BMI and OSA severity. At multiple regression, only lowest nocturnal oxygen saturation remained a significant contributor to IRF (r2 0.223, p<0.05). Conclusions. This data suggests that hypoxaemia due to OSA could influence the release of immature reticulocytes, but this effect is not mediated by erythropoietin.

AB - Background and Aim. The short, repetitive hypoxaemic episodes observed in obstructive sleep apnoea (OSA) may determine small augmentations in mature red blood cells. It is unknown whether they affect reticulocyte release. This study explored whether the number and degree of maturation of circulating reticulocytes may be altered in OSA, possibly through the effect of erythropoietin. Methods. Fifty male adult patients with suspected OSA, normoxic during wakefulness, were studied. After nocturnal polysomnography, a blood sample was withdrawn for blood cells count, erythropoietin, iron and transferrin determination. Reticulocyte concentration and degree of immaturity [high (H), medium (M), or low (L)] were also determined. Immature reticulocyte fraction (IRF) was calculated as (M+H) percentage of reticulocytes. Results. A wide range of OSA severity was found [apnoea/hypopnoea index (AHI): 44.3±30.4, range 0.3-105; sleep time spent at oxyhaemoglobin saturation <90%: 18.1±22.2%, range 0-81%]. Both reticulocyte count and IRF slightly exceeded the normal range. Patients with a reticulocyte concentration >2% had higher EPO levels (p<0.05), but not worse nocturnal desaturations, than those with values <2%. By contrast, subjects with IRF <15% showed worse desaturations (p<0.05), but similar EPO concentrations, when compared to subjects whose IRF was <10%. At univariate analysis, reticulocyte count correlated to erythropoietin, while IRF to transferrin saturation, BMI and OSA severity. At multiple regression, only lowest nocturnal oxygen saturation remained a significant contributor to IRF (r2 0.223, p<0.05). Conclusions. This data suggests that hypoxaemia due to OSA could influence the release of immature reticulocytes, but this effect is not mediated by erythropoietin.

KW - Haematopoiesis, Nocturnal hypoxemia, Obstructive sleep apnoea, Erythropoietin

UR - http://hdl.handle.net/10447/45987

M3 - Article

VL - 69

SP - 107

EP - 113

JO - Monaldi Archives for Chest Disease

JF - Monaldi Archives for Chest Disease

SN - 1122-0643

ER -