Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells.

Natale Belluardo, Giuseppa Mudo', Alessandra Bonomo, Laura Korhonen, Minna Kairisalo, Alessandra Bonomo, Alise Hyrskyluoto, Dan Lindholm

Risultato della ricerca: Article

34 Citazioni (Scopus)

Abstract

Resveratrol, a polyphenol derived e.g. from red grapes, has been shown to mediate several positive biological actions such as protection of cells against oxidative stress. It can also influence cell signaling, but the mechanisms behind its antioxidant properties are largely unknown. Here we show that RSV reduces oxidative stress and enhances cell survival in PC6.3 cells depending on the concentration. In these cells, RSV increased the levels of antioxidants, SOD2 and TRX2, and of X chromosome-linked inhibitor of apoptosis protein. RSV also activated NFκB signaling as shown using luciferase reporter constructs. These findings show that RSV regulates oxidative stress and mitochondrial antioxidants in neuronal cells. This may contribute to cell protection in various brain disorders.
Lingua originaleEnglish
pagine (da-a)263-266
Numero di pagine4
RivistaNeuroscience Letters
Volume488
Stato di pubblicazionePublished - 2011

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Oxidative Stress
Cell Death
Antioxidants
Cytoprotection
X-Linked Inhibitor of Apoptosis Protein
Vitis
Brain Diseases
X Chromosome
Polyphenols
Luciferases
Cell Survival
resveratrol

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells. / Belluardo, Natale; Mudo', Giuseppa; Bonomo, Alessandra; Korhonen, Laura; Kairisalo, Minna; Bonomo, Alessandra; Hyrskyluoto, Alise; Lindholm, Dan.

In: Neuroscience Letters, Vol. 488, 2011, pag. 263-266.

Risultato della ricerca: Article

Belluardo, Natale ; Mudo', Giuseppa ; Bonomo, Alessandra ; Korhonen, Laura ; Kairisalo, Minna ; Bonomo, Alessandra ; Hyrskyluoto, Alise ; Lindholm, Dan. / Resveratrol reduces oxidative stress and cell death and increases mitochondrial antioxidants and XIAP in PC6.3-cells. In: Neuroscience Letters. 2011 ; Vol. 488. pagg. 263-266.
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AU - Belluardo, Natale

AU - Mudo', Giuseppa

AU - Bonomo, Alessandra

AU - Korhonen, Laura

AU - Kairisalo, Minna

AU - Bonomo, Alessandra

AU - Hyrskyluoto, Alise

AU - Lindholm, Dan

PY - 2011

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AB - Resveratrol, a polyphenol derived e.g. from red grapes, has been shown to mediate several positive biological actions such as protection of cells against oxidative stress. It can also influence cell signaling, but the mechanisms behind its antioxidant properties are largely unknown. Here we show that RSV reduces oxidative stress and enhances cell survival in PC6.3 cells depending on the concentration. In these cells, RSV increased the levels of antioxidants, SOD2 and TRX2, and of X chromosome-linked inhibitor of apoptosis protein. RSV also activated NFκB signaling as shown using luciferase reporter constructs. These findings show that RSV regulates oxidative stress and mitochondrial antioxidants in neuronal cells. This may contribute to cell protection in various brain disorders.

KW - Resveratrol; XIAP; Oxidative stress; ROS; SOD2; TRX2; NFκB

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JF - Neuroscience Letters

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