Abstract

Purpose . Gambling disorder has been recently reclassified underthe category ‘‘substance-related and addictive disorders”. Recentstudies performed through functional MRI (fMRI) have shown thatthe perseverance of some behaviors can alter brain activation [1,2].In this work we aim at investigating functional connectivity changesin pathological gamblers (PGs) in comparison to healthy controls(HCs) by means of resting state functional Magnetic ResonanceImaging (rs-fMRI).Methods and materials. Thirteen HCs and fourteen PGs wererecruited (all right handed males; drugs free; mean age 36 ± 10yrs). All acquisitions were performed through a 1,5 T MRI scannerusing a 8-channels phased-array head coil. Multi-session temporalconcatenated Independent Component Analysis (concat-ICA) wascarried out to achieve activations information on functionally linkedbrain regions. The resulted components were then matched andcompared between groups. Correction for multiple comparisonsacross space was applied assuming an overall significance of p <temporal gyrus, right insula, right cerebellar hemisphere cortex andcerebellar vermis.Conclusion. We can conclude that an hyperconnectivity togetherwith an overactivation of specific regions is observed in PGs. The persistent activation of specific functional networks during gamblingtasks might represent the neurofunctional basis of PGs statereduced triggering threshold to gaming underlying the clinical features of gambling disorder. These preliminary results confirms thecrucial role of fMRI studies to investigate brain networks and theirchanges in specific clinical functional disorders.
Lingua originaleEnglish
pagine (da-a)75-76
Numero di pagine2
RivistaPHYSICA MEDICA
Volume56
Stato di pubblicazionePublished - 2018

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Gambling
Magnetic Resonance Imaging
Cerebellar Cortex
Brain
Temporal Lobe
Substance-Related Disorders
Head
Pharmaceutical Preparations

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@article{dcf950f0513f4a699d9f84227e0d0de2,
title = "Resting state functional magnetic resonance imaging analysis of the brain of pathological gamblers",
abstract = "Purpose . Gambling disorder has been recently reclassified underthe category ‘‘substance-related and addictive disorders”. Recentstudies performed through functional MRI (fMRI) have shown thatthe perseverance of some behaviors can alter brain activation [1,2].In this work we aim at investigating functional connectivity changesin pathological gamblers (PGs) in comparison to healthy controls(HCs) by means of resting state functional Magnetic ResonanceImaging (rs-fMRI).Methods and materials. Thirteen HCs and fourteen PGs wererecruited (all right handed males; drugs free; mean age 36 ± 10yrs). All acquisitions were performed through a 1,5 T MRI scannerusing a 8-channels phased-array head coil. Multi-session temporalconcatenated Independent Component Analysis (concat-ICA) wascarried out to achieve activations information on functionally linkedbrain regions. The resulted components were then matched andcompared between groups. Correction for multiple comparisonsacross space was applied assuming an overall significance of p <temporal gyrus, right insula, right cerebellar hemisphere cortex andcerebellar vermis.Conclusion. We can conclude that an hyperconnectivity togetherwith an overactivation of specific regions is observed in PGs. The persistent activation of specific functional networks during gamblingtasks might represent the neurofunctional basis of PGs statereduced triggering threshold to gaming underlying the clinical features of gambling disorder. These preliminary results confirms thecrucial role of fMRI studies to investigate brain networks and theirchanges in specific clinical functional disorders.",
author = "Carla Cannizzaro and Tommaso Piccoli and Maurizio Marrale and {La Barbera}, Daniele and Cesare Gagliardo and {La Tona}, Giuseppe and {La Cascia}, Caterina and Roberto Lagalla and Giuseppe Maniaci and Giorgio Collura and Francesca Picone",
year = "2018",
language = "English",
volume = "56",
pages = "75--76",
journal = "PHYSICA MEDICA",
issn = "1724-191X",

}

TY - JOUR

T1 - Resting state functional magnetic resonance imaging analysis of the brain of pathological gamblers

AU - Cannizzaro, Carla

AU - Piccoli, Tommaso

AU - Marrale, Maurizio

AU - La Barbera, Daniele

AU - Gagliardo, Cesare

AU - La Tona, Giuseppe

AU - La Cascia, Caterina

AU - Lagalla, Roberto

AU - Maniaci, Giuseppe

AU - Collura, Giorgio

AU - Picone, Francesca

PY - 2018

Y1 - 2018

N2 - Purpose . Gambling disorder has been recently reclassified underthe category ‘‘substance-related and addictive disorders”. Recentstudies performed through functional MRI (fMRI) have shown thatthe perseverance of some behaviors can alter brain activation [1,2].In this work we aim at investigating functional connectivity changesin pathological gamblers (PGs) in comparison to healthy controls(HCs) by means of resting state functional Magnetic ResonanceImaging (rs-fMRI).Methods and materials. Thirteen HCs and fourteen PGs wererecruited (all right handed males; drugs free; mean age 36 ± 10yrs). All acquisitions were performed through a 1,5 T MRI scannerusing a 8-channels phased-array head coil. Multi-session temporalconcatenated Independent Component Analysis (concat-ICA) wascarried out to achieve activations information on functionally linkedbrain regions. The resulted components were then matched andcompared between groups. Correction for multiple comparisonsacross space was applied assuming an overall significance of p <temporal gyrus, right insula, right cerebellar hemisphere cortex andcerebellar vermis.Conclusion. We can conclude that an hyperconnectivity togetherwith an overactivation of specific regions is observed in PGs. The persistent activation of specific functional networks during gamblingtasks might represent the neurofunctional basis of PGs statereduced triggering threshold to gaming underlying the clinical features of gambling disorder. These preliminary results confirms thecrucial role of fMRI studies to investigate brain networks and theirchanges in specific clinical functional disorders.

AB - Purpose . Gambling disorder has been recently reclassified underthe category ‘‘substance-related and addictive disorders”. Recentstudies performed through functional MRI (fMRI) have shown thatthe perseverance of some behaviors can alter brain activation [1,2].In this work we aim at investigating functional connectivity changesin pathological gamblers (PGs) in comparison to healthy controls(HCs) by means of resting state functional Magnetic ResonanceImaging (rs-fMRI).Methods and materials. Thirteen HCs and fourteen PGs wererecruited (all right handed males; drugs free; mean age 36 ± 10yrs). All acquisitions were performed through a 1,5 T MRI scannerusing a 8-channels phased-array head coil. Multi-session temporalconcatenated Independent Component Analysis (concat-ICA) wascarried out to achieve activations information on functionally linkedbrain regions. The resulted components were then matched andcompared between groups. Correction for multiple comparisonsacross space was applied assuming an overall significance of p <temporal gyrus, right insula, right cerebellar hemisphere cortex andcerebellar vermis.Conclusion. We can conclude that an hyperconnectivity togetherwith an overactivation of specific regions is observed in PGs. The persistent activation of specific functional networks during gamblingtasks might represent the neurofunctional basis of PGs statereduced triggering threshold to gaming underlying the clinical features of gambling disorder. These preliminary results confirms thecrucial role of fMRI studies to investigate brain networks and theirchanges in specific clinical functional disorders.

UR - http://hdl.handle.net/10447/373674

M3 - Book/Film/Article review

VL - 56

SP - 75

EP - 76

JO - PHYSICA MEDICA

JF - PHYSICA MEDICA

SN - 1724-191X

ER -