Abstract

Purpose . Gambling disorder has been recently reclassified underthe category ‘‘substance-related and addictive disorders”. Recentstudies performed through functional MRI (fMRI) have shown thatthe perseverance of some behaviors can alter brain activation [1,2].In this work we aim at investigating functional connectivity changesin pathological gamblers (PGs) in comparison to healthy controls(HCs) by means of resting state functional Magnetic ResonanceImaging (rs-fMRI).Methods and materials. Thirteen HCs and fourteen PGs wererecruited (all right handed males; drugs free; mean age 36 ± 10yrs). All acquisitions were performed through a 1,5 T MRI scannerusing a 8-channels phased-array head coil. Multi-session temporalconcatenated Independent Component Analysis (concat-ICA) wascarried out to achieve activations information on functionally linkedbrain regions. The resulted components were then matched andcompared between groups. Correction for multiple comparisonsacross space was applied assuming an overall significance of p <temporal gyrus, right insula, right cerebellar hemisphere cortex andcerebellar vermis.Conclusion. We can conclude that an hyperconnectivity togetherwith an overactivation of specific regions is observed in PGs. The persistent activation of specific functional networks during gamblingtasks might represent the neurofunctional basis of PGs statereduced triggering threshold to gaming underlying the clinical features of gambling disorder. These preliminary results confirms thecrucial role of fMRI studies to investigate brain networks and theirchanges in specific clinical functional disorders.
Lingua originaleEnglish
pagine (da-a)75-76
Numero di pagine2
RivistaPHYSICA MEDICA
Volume56
Stato di pubblicazionePublished - 2018

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