Resting Energy expenditure in type 2 diabetic patients and the effect of insulin bolus

Maria Donatelli, Salvatore Verga, Sonya Vasto, Silvio Buscemi, Giuseppe Grosso, Flavia Costa, Giuseppe Grosso, Fabio Galvano

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12 Citazioni (Scopus)


Aims: Resting energy expenditure (REE) plays a critical role in the regulation of body weight,with important implications in type 2 diabetes (T2D). However, the relationships betweenREE and T2D have not been extensively evaluated. We compared REE in persons withdiabetes and in persons without diabetes. We also investigated the acute effect of insulin onREE and venous lactate, the latter an indirect measure of neoglucogenetic activity.Methods: REE was measured using indirect calorimetry in 14 newly diagnosed, untreatedT2D adults and in 14 non-diabetic age-, gender- and body mass index-matched persons. TheREE and lactate venous concentrations were also measured in a subgroup of 5 T2D patientsin the hour following an IV insulin bolus.Results: The REE normalized for fat-free mass (FFM) was significantly higher in T2D patientsthan in the group without diabetes (mean SD: 27.6 1.9 vs. 25.8 1.9 kcal/kg-FFM 24 h;P = 0.02). REE normalized for FFM was correlated with fasting plasma glucose concentration(r = 0.51; P = 0.005). Following the insulin venous bolus REE (00: 2048 242; 100: 1804 228; 200:1684 230; 300: 1634 212; 450: 1594 179; 600: 1625 197 kcal/24 h; P < 0.001) and bothglucose (P < 0.001) and lactate (P < 0.001) concentrations progressively declined in theensuing hour.Conclusions: Patients with diabetes have a higher energy expenditure, likely a consequenceof higher gluconeogenetic activity. This study may contribute to recognizing the nature ofbody weight reduction that occurs in concomitance with poorly controlled diabetes, and ofbody weight gain as commonly observed when hypoglycemic treatment is started.
Lingua originaleEnglish
Numero di pagine6
RivistaDiabetes Research and Clinical Practice
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2712???
  • ???subjectarea.asjc.1300.1310???


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