Resonant activation in polymertranslocation: new insights into theescape dynamics of molecules driven byan oscillating field

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Abstract

The translocation of molecules across cellular membranes or through synthetic nanopores isstrongly affected by thermal fluctuations. In this work we study how the dynamics of apolymer in a noisy environment changes when the translocation process is driven by anoscillating electric field. An improved version of the Rouse model for a flexible polymer hasbeen adopted to mimic the molecular dynamics, by taking into account the harmonicinteractions between adjacent monomers and the excluded-volume effect by introducing aLennard–Jones potential between all beads. A bending recoil torque has also been included inour model. The polymer dynamics is simulated in a two-dimensional domain by numericallysolving the Langevin equations of motion. Thermal fluctuations are taken into account byintroducing a Gaussian uncorrelated noise. The mean first translocation time of the polymercentre of inertia shows a minimum as a function of the frequency of the oscillating forcingfield. This finding represents the first evidence of the resonant activation behaviour in thedynamics of polymer translocation.
Lingua originaleEnglish
pagine (da-a)034001-1-034001-5
Numero di pagine5
RivistaPhysical Biology
Volume7
Stato di pubblicazionePublished - 2010

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Molecular Biology
  • Cell Biology

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