The translocation of molecules across cellular membranes or through synthetic nanopores isstrongly affected by thermal fluctuations. In this work we study how the dynamics of apolymer in a noisy environment changes when the translocation process is driven by anoscillating electric field. An improved version of the Rouse model for a flexible polymer hasbeen adopted to mimic the molecular dynamics, by taking into account the harmonicinteractions between adjacent monomers and the excluded-volume effect by introducing aLennard–Jones potential between all beads. A bending recoil torque has also been included inour model. The polymer dynamics is simulated in a two-dimensional domain by numericallysolving the Langevin equations of motion. Thermal fluctuations are taken into account byintroducing a Gaussian uncorrelated noise. The mean first translocation time of the polymercentre of inertia shows a minimum as a function of the frequency of the oscillating forcingfield. This finding represents the first evidence of the resonant activation behaviour in thedynamics of polymer translocation.
|Numero di pagine||5|
|Stato di pubblicazione||Published - 2010|
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology
- Cell Biology