Reproducible Coronary Plaque Quantification by Multislice Computed Tomography

Ludovico La Grutta, Alessandro Palumbo, Ludovico La Grutta, Serruys, Jos R.T.C. Roelandt, Pim J. De Feijter, Nico Mollet, Nico Bruining, Ron T. Van Domburg, Ronald Hamers, Filippo Cademartiri

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30 Citazioni (Scopus)


Background: The aim of this study was to investigate reproducibility end accuracy of computer-assisted coronary plaque measurements by multislice computed tomography coronary angiography (QMSCT-CA). Methods and Results: Forty-sight patients undergoing MSCT-CA end coronary arteriography for symptomatic coronary artery disease and quantitative intravascular ultrasound (IVUS, QCU) were examined. Two investigators performed the QMSCT-CA twice end e third investigator performed the QCU, all blinded for each other's results. There was no difference found for the matched region of interest (ROI) lengths (QCU 29.4 ± 13 mm vs. QMSCT-CA 29.6 ± 13 mm, P = 0.6; total length = 1,400 mm). The comparison of volumetric measurements showed (lumen QCU 267 ± 139 mm3 vs. mean QMSCT-CA 177 ± 91 mm3, P < 0.001; vessel 454 ± 194 mm3 vs. 398 ± 187 mm 3, P < 0.001; and plaque 189 ± 93 mm3 vs. 222 ± 121 mm3; investigator 1, P = 0.02; and investigator 2, P = 0.07) significant differences. Automated lumen detection was also applied for QMSCT-CA (218 ± 112 mm3, P < 0.001 vs. QCU). The Interinvestigator variability measurements for QMSCT-CA showed no significant differences. Conclusion: QMSCT-CA systematically underestimates absolute coronary lumen- and vessel dimensions when compared with QCU. However, repeated measurements of coronary plaque by QMSCT-CA showed no statistically significant differences, although, the outcome showed a scattered result. Automated lumen detection for QMSCT-CA showed improved results when compered with those of human investigators.
Lingua originaleEnglish
pagine (da-a)857-865
Numero di pagine9
RivistaCatheterization and Cardiovascular Interventions
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

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