Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter study

Vincenzo La Bella, Cristina Moglia, Francesca Valentino, Gianluigi Mancardi, Cristina Moglia, Francesca Valentino, Roberto Mutani, Amelia Conte, Cecilia Carlesi, Marco Luigetti, Mario Melazzini, Francesca Gualandi, Corrado Tarella, Stefania Mantovani, Marco Ulla, Maria Mascolo, Andrea Calvo, Silvia Garbelli, Paola Bondesan, Dario AlimontiPatrizia Bossolasco, Francesco Onida, Claudia Caponnetto, Mario Sabatelli, Paola Omedé, Rosanna Scimè, Sergio Rutella, Andrea Calvo, Giorgio Lambertenghi Deliliers, Gabriele Siciliano, Caterina Bendotti, Vincenzo Silani, Adriano Chiò, Massimo Corbo, Mario Petrini, Gabriele Mora, Pietro Attilio Tonali, Paolo Ghiglione

Risultato della ricerca: Articlepeer review

53 Citazioni (Scopus)

Abstract

Granulocyte colony-stimulating factor (G-CSF) induces a transient mobilization of hematopoietic progenitor cells from bone marrow to peripheral blood. Our aim was to evaluate safety of repeated courses of G-CSF in patients with amyotrophic lateral sclerosis (ALS), assessing disease progression and changes in chemokine and cytokine levels in serum and cerebrospinal fluid (CSF). Twenty-four ALS patients entered an open-label, multicenter trial in which four courses of G-CSF and mannitol were administered at 3-month intervals. Levels of G-CSF were increased after treatment in the serum and CSF. Few and transitory adverse events were observed. No significant reduction of the mean monthly decrease in ALSFRS-R score and forced vital capacity was observed. A significant reduction in CSF levels of monocyte chemoattractant protein-1 (MCP-1) and interleukin-17 (IL-17) was observed. G-CSF treatment was safe and feasible in a multicenter series of ALS patients. A decrease in the CSF levels of proinflammatory cytokines MCP-1 and IL-17 was found, indicating a G-CSF-induced central anti-inflammatory response
Lingua originaleEnglish
pagine (da-a)189-195
Numero di pagine7
RivistaMUSCLE & NERVE
Volume43
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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