TY - JOUR
T1 - Renin-Angiotensin System Inhibition in Cardiovascular Patients at the Time of COVID19: Much Ado for Nothing? A Statement of Activity from the Directors of the Board and the Scientific Directors of the Italian Society of Hypertension
AU - Mule', Giuseppe
AU - Grassi, Guido
AU - Sechi, Leonardo Alberto
AU - Borghi, Claudio
AU - Iaccarino, Guido
AU - Iaccarino, Guido
AU - Iaccarino, Guido
AU - Savoia, Carmine
AU - Cicero, Arrigo F. G.
AU - Minuz, Pietro
AU - Mulatero, Paolo
AU - Iaccarino, Guido
AU - Muiesan, Maria Lorenza
AU - Salvetti, Massimo
AU - Volpe, Massimo
AU - Borghi, Claudio
AU - Ferri, Claudio
AU - Pucci, Giacomo
PY - 2020
Y1 - 2020
N2 - Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin-Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. In vitro studies are available to support the eventual role of ACE inhibitors and ARBs in both the promotion and antagonism of the disease. The available literature, indeed, presents contrasting results, all concentrated in experimental models. Evidence in humans is lacking that those mechanisms are actually occurring in the present COVID-19 outbreak. Here we present the reasoned statement of the Italian Society of Hypertension to maintain ongoing antihypertensive treatments. Furthermore, the Italian Society of Hypertension presents its own initiative to investigate the issue using an online questionnaire to collect relevant data in human disease.
AB - Cardiovascular diseases, in particular hypertension, as well as the cardiovascular treatment with Renin-Angiotensin System inhibitors such as Angiotensin Converting Enzyme (ACE) inhibitors and Angiotensin Receptor Blockers (ARBs), are claimed once again as mechanisms of Severe Acute Respiratory Syndrome (SARS) during the COVID-19 outbreak due to Cov-2 epidemics. In vitro studies are available to support the eventual role of ACE inhibitors and ARBs in both the promotion and antagonism of the disease. The available literature, indeed, presents contrasting results, all concentrated in experimental models. Evidence in humans is lacking that those mechanisms are actually occurring in the present COVID-19 outbreak. Here we present the reasoned statement of the Italian Society of Hypertension to maintain ongoing antihypertensive treatments. Furthermore, the Italian Society of Hypertension presents its own initiative to investigate the issue using an online questionnaire to collect relevant data in human disease.
UR - http://hdl.handle.net/10447/414050
UR - https://link.springer.com/article/10.1007/s40292-020-00380-3
M3 - Article
VL - 27
SP - 105
EP - 108
JO - HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
JF - HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION
SN - 1120-9879
ER -