Renal haemodynamics and severity of carotid atherosclerosis in hypertensive patientswith and without impaired renal function

Santina Cottone, Giulio Geraci, Calogero Geraci, Giuseppe Mule', Chiara Guglielmo, Manuela Mogavero

Risultato della ricerca: Articlepeer review

32 Citazioni (Scopus)


Background and Aim. Renal resistance index (RRI), assessed by Duplex-Doppler sonography, hasbeen classically considered as a mere expression of intrarenal vascular resistance. Recent studies,however, have showed that RRI is also influenced by upstream factors, especially arterialcompliance, confirming its possible role as a marker of systemic vascular alterations.Several studies have shown that carotid intima-media thickness (cIMT) and carotid plaques (cP),assessed by ultrasonography, are documented markers of subclinical organ damage as well asexpression of progressive atherosclerotic disease, and that they get worse with the progressivedeterioration of renal function.The study was aimed to evaluate the relationship between RRI and severity of carotidatherosclerosis in hypertensive subjects with and without impaired renal function.Methods and Results. The study population, including 263 hypertensive patients (30-70 years), wassplit into 3 groups based on cIMT and presence of cP (cIMT≤0.9 mm and no cP; cIMT>0.9 mm and nocP; cP). All patients were also divided into 2 subgroups (normal renal function;CKD stage I-IV).A stepwise increase in RRI corresponding to the groups of progressive severity of carotidatherosclerosis was observed (respectively 0.61±0.07, 0.65±0.06, 0.68±0.06; p<0.001). A strongpositive correlation was observed between RRI and cIMT in the whole population (r=0.43;p<0.001)and in the subgroups with (r=0.42;p<0.001) and without (r=0.39;p<0.001) CKD. These associationsremained statistically significant even after adjustment for various confounding factors.Conclusion. Showing a close association between RRI and severity of carotid atherosclerosis, ourresults strengthen the concept that RRI is a marker of systemic vascular changes.
Lingua originaleEnglish
pagine (da-a)160-166
Numero di pagine7
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2700.2712???
  • ???subjectarea.asjc.2900.2916???
  • ???subjectarea.asjc.2700.2705???


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