Transbuccal drug delivery has got several well-known advantages especially with respect to peroral way. Since a major limitation in buccal drug delivery could be the low permeability of the epithelium, the aptitude of NLX to penetrate the mucosal barrier was assessed.Ex vivo permeation across porcine buccal mucosa 800 lm thick was investigated using Franz type diﬀusion cells and compared with in vitro data previously obtained by reconstituted human oral epithelium 100 micrometer thick. Both ﬂuxes (Js) and permeability coeﬃcients(Kp) are in accordance, using either buﬀer solution simulating saliva or natural human saliva. Permeation was evaluated also in presence of chemical enhancers or iontophoresis. No signiﬁcant diﬀerences in penetration rate were observed using chemical enhancers; in contrast, Js and Kp were extensively aﬀected by application of electric ﬁelds. Tablets, designed for Naltrexone hydrochloride (NLX)administration on buccal mucosa, were developed and prepared by direct compression of drug loaded (56%) poly-octylcyanocrylate (poly-OCA) matrices. NLX is slowly discharged from buccal tablets following Higuchian kinetic. Histologically, no signs of ﬂogosisascribable to NLX and/or poly-OCA were observed, while cytoarchitectural changes due to iontophoresis were detected. Buccal tablets containing NLX may represent a potential alternative dosage form in addiction management.
|Numero di pagine||9|
|Rivista||European Journal of Pharmaceutics and Biopharmaceutics|
|Stato di pubblicazione||Published - 2007|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science