Relationship between quality of life and behavioural disorders in children with persistent asthma: a Multiple Indicators Multiple Causes (MIMIC) model.

Giuliana Ferrante, Sabrina Di Pillo, Silvia Montella, Amelia Licari, Duse, Mariangela Tosca, Laura Tenero, Gianluigi Marseglia, Sara Bozzetto, Emanuela Di Palmo, Valeria Caldarelli, Grazia Fenu, Michele Ghezzi, Antonino Capizzi, Amarri, Giampaolo Ricci, Laura Montalbano, Lucia Leonardi, Giovanna Cilluffo, VolpiniPiacentini, Tripodi, Michele Ghezzi, Pisi, Luana Nosetti, Salvatore Cazzato, Maria Francesca Patria, Pisi, Carraro, Stefania La Grutta, Franca Rusconi, Kantar, Sacco, Renato Cutrera, Giorgio Piacentini, Fabio Cardinale, Antonio Di Marco, Enrico Lombardi, Elio Novembre, Leonardi, Francesca Santamaria, Simona Barni

Risultato della ricerca: Articlepeer review

6 Citazioni (Scopus)

Abstract

Knowledge on multiple interdependences between quality of life (QoL) and behavioural problems in relation to asthma severity and control is undetermined. The aims of the study were: (i) to assess the relationship of QoL and behavioural problems with asthma severity and control (ii) to predict children's "abnormal/borderline" status with variation in QoL. For these purposes a multicenter case-control study on 47 Severe Asthma (SA) and 94 Moderate Asthma (MA) children was performed. The MIMIC approach was applied to investigate the effect of SA and non-controlled asthma (NC) on QoL and behavioural disorders. Logistic regression was used to estimate probabilities of having an "abnormal/borderline" status with variation in QoL. The MIMIC model showed that the magnitude of the effect of SA and NC was larger on QoL (β = -0.37 and β = -0.30, respectively) than on behavioural problems (β = 0.27). With regards to the probability of having a borderline status, in MA a QoL of 1 returned a probability of 0.81, whereas in SA a QoL of 1 returned a probability of 0.89. In conclusion, SA children are highly affected by impaired QoL and behavioural problems. The MIMIC model allowed us to obtain a comprehensive assessment of QoL and behavioural problems with asthma severity and control.
Lingua originaleEnglish
Numero di pagine9
RivistaScientific Reports
Volume10
Stato di pubblicazionePublished - 2020

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