Relationship between kidney findings and systemic vascular damage in elderly hypertensive patients without overt cardiovascular disease

Giuseppe Mule', Giulio Geraci, Pasquale Mansueto, Santina Cottone, Calogero Geraci, Antonio Granata, Antonella Castiglia, Federica Zotta, Girolama Gabriella Paladino

Risultato della ricerca: Article

6 Citazioni (Scopus)

Abstract

Few studies have investigated the influence of age on the relationships between systemic vascular damage, kidney dysfunction, and intrarenal hemodynamic changes in patients with hypertension without overt cardiovascular disease. The authors enrolled 126 elderly patients with hypertension (aged ≥65 years) and 350 nonelderly patients with hypertension (aged <65 years). Carotid intima-media thickness, renal resistive index, and aortic pulse wave velocity were performed in all patients. Elderly patients with hypertension had lower estimated glomerular filtration rates and higher albuminuria, renal resistive index, carotid intima-media thickness, and aortic pulse wave velocity compared with nonelderly patients with hypertension (P < .001). Carotid intima-media thickness independently correlated with renal resistive index and estimated glomerular filtration rate in nonelderly patients with hypertension, whereas it was significantly related to renal resistive index only in elderly patients with hypertension. Aortic pulse wave velocity was independently associated with albuminuria in nonelderly patients with hypertension, whereas it did not independently correlate with any indexes of renal damage in elderly patients with hypertension. Age is an important modifier of the relationships between renal function and renal hemodynamics with subclinical vascular involvement in elderly persons without cardiovascular disease.
Lingua originaleEnglish
pagine (da-a)1339-1347
Numero di pagine9
RivistaTHE JOURNAL OF CLINICAL HYPERTENSION
Volume19
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

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