RELATIONSHIP BETWEEN ASYMPTOMATIC HYPERURICEMIA AND RENAL FUNCTION DECLINE IN HYPERTENSIVE SUBJECTS.

Giuseppe Mule', Francesco Vaccaro, Santina Cottone, Laura Guarino, Anna Carola Foraci, Cristiano Guido, Dario Altieri, Francesco D'Ignoto, Massimiliano Morreale, Tania Bellavia

Risultato della ricerca: Other

Abstract

Introduction: It is well known that the deposition of uricacid crystals exert direct toxic effect on the renal parenchymaand vasculature. Both experimental and someclinical studies suggest the possibility that an increased uricacid level can lead to kidney disease even without depositionof uric acid crystals. However, other studies yieldedconflicting results, especially regarding the role of uric acidin the progression of established kidney disease.Aim: To evaluate retrospectively the relationship betweenasymptomatic hyperuricemia and renal function decline innon-gouty hypertensive patients.Methods: We enrolled 97 hypertensive subjects, 48 withchronic kidney diseases (CKD) and 49 without CKD. Fiftysevenof them had normal (N) serum uric acid (SUA) level(SUA\7 mg/dl in men and\6 mg/dl in women) and 40had hyperuricemia (U). Patients with hyperuricemia hadhigher systolic blood pressures and lower estimated glomerularfiltration rate (eGFR) than N. At the end of followupperiod (mean: 16 months), eGFR reduction was similarin the two groups (N: -3.6 ± 12.3; U: -3 ± 13.4 ml/min/1.73 m2).186Results: Two-way ANOVA showed that this result was notinfluenced by renal dysfunction, diabetes, macroproteinuria,gender or smoking habit. The percentage of subjectswith a value of eGFR reduction above the median was notsignificantly different in the two groups (N: 24.6 %; U:27.5 %). The absence of a significant difference betweenthe two groups, regarding the eGFR decline was confirmedby the multiple logistic regression analysis, where thevariables associated with a greater eGFR reduction wereonly the proteinuria and the smoking habit.Conclusions: Our findings do not support the hypothesis ofa significant effect of asymptomatic hyperuricemia on therenal function decline in subjects with arterialhypertension.
Lingua originaleEnglish
Pagine186-186
Numero di pagine1
Stato di pubblicazionePublished - 2013

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Hyperuricemia
Kidney Diseases
Uric Acid
Kidney
Habits
Smoking
Blood Pressure
Poisons
Serum
Proteinuria
Analysis of Variance
Logistic Models
Regression Analysis

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RELATIONSHIP BETWEEN ASYMPTOMATIC HYPERURICEMIA AND RENAL FUNCTION DECLINE IN HYPERTENSIVE SUBJECTS. / Mule', Giuseppe; Vaccaro, Francesco; Cottone, Santina; Guarino, Laura; Foraci, Anna Carola; Guido, Cristiano; Altieri, Dario; D'Ignoto, Francesco; Morreale, Massimiliano; Bellavia, Tania.

2013. 186-186.

Risultato della ricerca: Other

Mule', G, Vaccaro, F, Cottone, S, Guarino, L, Foraci, AC, Guido, C, Altieri, D, D'Ignoto, F, Morreale, M & Bellavia, T 2013, 'RELATIONSHIP BETWEEN ASYMPTOMATIC HYPERURICEMIA AND RENAL FUNCTION DECLINE IN HYPERTENSIVE SUBJECTS.', pagg. 186-186.
Mule', Giuseppe ; Vaccaro, Francesco ; Cottone, Santina ; Guarino, Laura ; Foraci, Anna Carola ; Guido, Cristiano ; Altieri, Dario ; D'Ignoto, Francesco ; Morreale, Massimiliano ; Bellavia, Tania. / RELATIONSHIP BETWEEN ASYMPTOMATIC HYPERURICEMIA AND RENAL FUNCTION DECLINE IN HYPERTENSIVE SUBJECTS. 1 pag.
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title = "RELATIONSHIP BETWEEN ASYMPTOMATIC HYPERURICEMIA AND RENAL FUNCTION DECLINE IN HYPERTENSIVE SUBJECTS.",
abstract = "Introduction: It is well known that the deposition of uricacid crystals exert direct toxic effect on the renal parenchymaand vasculature. Both experimental and someclinical studies suggest the possibility that an increased uricacid level can lead to kidney disease even without depositionof uric acid crystals. However, other studies yieldedconflicting results, especially regarding the role of uric acidin the progression of established kidney disease.Aim: To evaluate retrospectively the relationship betweenasymptomatic hyperuricemia and renal function decline innon-gouty hypertensive patients.Methods: We enrolled 97 hypertensive subjects, 48 withchronic kidney diseases (CKD) and 49 without CKD. Fiftysevenof them had normal (N) serum uric acid (SUA) level(SUA\7 mg/dl in men and\6 mg/dl in women) and 40had hyperuricemia (U). Patients with hyperuricemia hadhigher systolic blood pressures and lower estimated glomerularfiltration rate (eGFR) than N. At the end of followupperiod (mean: 16 months), eGFR reduction was similarin the two groups (N: -3.6 ± 12.3; U: -3 ± 13.4 ml/min/1.73 m2).186Results: Two-way ANOVA showed that this result was notinfluenced by renal dysfunction, diabetes, macroproteinuria,gender or smoking habit. The percentage of subjectswith a value of eGFR reduction above the median was notsignificantly different in the two groups (N: 24.6 {\%}; U:27.5 {\%}). The absence of a significant difference betweenthe two groups, regarding the eGFR decline was confirmedby the multiple logistic regression analysis, where thevariables associated with a greater eGFR reduction wereonly the proteinuria and the smoking habit.Conclusions: Our findings do not support the hypothesis ofa significant effect of asymptomatic hyperuricemia on therenal function decline in subjects with arterialhypertension.",
keywords = "Uric acid, arterial hypertension, asymptomatic hyperuricemia, renal function decline",
author = "Giuseppe Mule' and Francesco Vaccaro and Santina Cottone and Laura Guarino and Foraci, {Anna Carola} and Cristiano Guido and Dario Altieri and Francesco D'Ignoto and Massimiliano Morreale and Tania Bellavia",
year = "2013",
language = "English",
pages = "186--186",

}

TY - CONF

T1 - RELATIONSHIP BETWEEN ASYMPTOMATIC HYPERURICEMIA AND RENAL FUNCTION DECLINE IN HYPERTENSIVE SUBJECTS.

AU - Mule', Giuseppe

AU - Vaccaro, Francesco

AU - Cottone, Santina

AU - Guarino, Laura

AU - Foraci, Anna Carola

AU - Guido, Cristiano

AU - Altieri, Dario

AU - D'Ignoto, Francesco

AU - Morreale, Massimiliano

AU - Bellavia, Tania

PY - 2013

Y1 - 2013

N2 - Introduction: It is well known that the deposition of uricacid crystals exert direct toxic effect on the renal parenchymaand vasculature. Both experimental and someclinical studies suggest the possibility that an increased uricacid level can lead to kidney disease even without depositionof uric acid crystals. However, other studies yieldedconflicting results, especially regarding the role of uric acidin the progression of established kidney disease.Aim: To evaluate retrospectively the relationship betweenasymptomatic hyperuricemia and renal function decline innon-gouty hypertensive patients.Methods: We enrolled 97 hypertensive subjects, 48 withchronic kidney diseases (CKD) and 49 without CKD. Fiftysevenof them had normal (N) serum uric acid (SUA) level(SUA\7 mg/dl in men and\6 mg/dl in women) and 40had hyperuricemia (U). Patients with hyperuricemia hadhigher systolic blood pressures and lower estimated glomerularfiltration rate (eGFR) than N. At the end of followupperiod (mean: 16 months), eGFR reduction was similarin the two groups (N: -3.6 ± 12.3; U: -3 ± 13.4 ml/min/1.73 m2).186Results: Two-way ANOVA showed that this result was notinfluenced by renal dysfunction, diabetes, macroproteinuria,gender or smoking habit. The percentage of subjectswith a value of eGFR reduction above the median was notsignificantly different in the two groups (N: 24.6 %; U:27.5 %). The absence of a significant difference betweenthe two groups, regarding the eGFR decline was confirmedby the multiple logistic regression analysis, where thevariables associated with a greater eGFR reduction wereonly the proteinuria and the smoking habit.Conclusions: Our findings do not support the hypothesis ofa significant effect of asymptomatic hyperuricemia on therenal function decline in subjects with arterialhypertension.

AB - Introduction: It is well known that the deposition of uricacid crystals exert direct toxic effect on the renal parenchymaand vasculature. Both experimental and someclinical studies suggest the possibility that an increased uricacid level can lead to kidney disease even without depositionof uric acid crystals. However, other studies yieldedconflicting results, especially regarding the role of uric acidin the progression of established kidney disease.Aim: To evaluate retrospectively the relationship betweenasymptomatic hyperuricemia and renal function decline innon-gouty hypertensive patients.Methods: We enrolled 97 hypertensive subjects, 48 withchronic kidney diseases (CKD) and 49 without CKD. Fiftysevenof them had normal (N) serum uric acid (SUA) level(SUA\7 mg/dl in men and\6 mg/dl in women) and 40had hyperuricemia (U). Patients with hyperuricemia hadhigher systolic blood pressures and lower estimated glomerularfiltration rate (eGFR) than N. At the end of followupperiod (mean: 16 months), eGFR reduction was similarin the two groups (N: -3.6 ± 12.3; U: -3 ± 13.4 ml/min/1.73 m2).186Results: Two-way ANOVA showed that this result was notinfluenced by renal dysfunction, diabetes, macroproteinuria,gender or smoking habit. The percentage of subjectswith a value of eGFR reduction above the median was notsignificantly different in the two groups (N: 24.6 %; U:27.5 %). The absence of a significant difference betweenthe two groups, regarding the eGFR decline was confirmedby the multiple logistic regression analysis, where thevariables associated with a greater eGFR reduction wereonly the proteinuria and the smoking habit.Conclusions: Our findings do not support the hypothesis ofa significant effect of asymptomatic hyperuricemia on therenal function decline in subjects with arterialhypertension.

KW - Uric acid

KW - arterial hypertension

KW - asymptomatic hyperuricemia

KW - renal function decline

UR - http://hdl.handle.net/10447/84027

M3 - Other

SP - 186

EP - 186

ER -