RELATIONSHIP BETWEEN AORTIC PULSE WAVE VELOCITY AND RENAL RESISTIVE INDEX IN HYPERTENSIVE PATIENTS.

Mule’, G; Cottone S.

Risultato della ricerca: Paper

Abstract

INTRODUCTION: The assessment of renal hemodynamic parameters by duplex Doppler sonography has been used for many years as a diagnostic tool in the daily workup of kidney diseases. Recent data suggest that these parameters, especially the intrarenal resistive index (RI), may be also associated with systemic vascular changes and cardiovascular risk. However, conflicting data exist about the independent association of aortic stiffness with RI. AIM: The aim was to evaluate the relationship between RI and arterial stiffness, assessed by aortic pulse wave velocity (PWV), in the hypertensive subjects consecutively attending our hypertension centre. METHODS: We enrolled 264 subjects, aged between 30 and 70 years. They were divided into two groups, either with normal renal function (n = 140) or with chronic kidney disease (CKD), ranging from stage 1 to stage 4 of the KDIGO classification (n = 124). RESULTS: The aortic PWV was measured by a computerized oscillometric method (Arteriograph). The GFR was estimated byCKD-EPI equation.Asingle operator performed duplex Doppler assessment of the renal arteries. Doppler signals were obtained by placing the sample volume along the course of the interlobar arteries. The RI was calculated as the average of six measurements (three from each kidney). Patients with PWV> 12 m/s showed higher values of RI, both in the overall population (p< 0.001) and in the subgroups with (p<0.01) and without CKD (p<0.01). In addition, a statistically significant correlation was observed between aortic PWV and RI in the whole population (r = 0.38, p<0.001) and in the subgroups with (r = 0.35, p<0.001) and without CKD (r = 0:31, p<0.001). These correlations held even after adjustment for several confounding factors. CONCLUSIONS: Showing a strong independent association between renal RI and aortic PWV, seem to corroborate the concept that the RI, beyond its prognostic renal value, may be considered as a marker of systemic vascular changes and therefore a predictor of cardiovascular risk.
Lingua originaleEnglish
Stato di pubblicazionePublished - 2013

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Pulse Wave Analysis
Kidney
Chronic Renal Insufficiency
Vascular Stiffness
Blood Vessels
Doppler Duplex Ultrasonography
Kidney Diseases
Renal Artery
Population
Arteries
Hemodynamics
Hypertension

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@conference{f9c1b9f357234e7abad7085f2b9fe633,
title = "RELATIONSHIP BETWEEN AORTIC PULSE WAVE VELOCITY AND RENAL RESISTIVE INDEX IN HYPERTENSIVE PATIENTS.",
abstract = "INTRODUCTION: The assessment of renal hemodynamic parameters by duplex Doppler sonography has been used for many years as a diagnostic tool in the daily workup of kidney diseases. Recent data suggest that these parameters, especially the intrarenal resistive index (RI), may be also associated with systemic vascular changes and cardiovascular risk. However, conflicting data exist about the independent association of aortic stiffness with RI. AIM: The aim was to evaluate the relationship between RI and arterial stiffness, assessed by aortic pulse wave velocity (PWV), in the hypertensive subjects consecutively attending our hypertension centre. METHODS: We enrolled 264 subjects, aged between 30 and 70 years. They were divided into two groups, either with normal renal function (n = 140) or with chronic kidney disease (CKD), ranging from stage 1 to stage 4 of the KDIGO classification (n = 124). RESULTS: The aortic PWV was measured by a computerized oscillometric method (Arteriograph). The GFR was estimated byCKD-EPI equation.Asingle operator performed duplex Doppler assessment of the renal arteries. Doppler signals were obtained by placing the sample volume along the course of the interlobar arteries. The RI was calculated as the average of six measurements (three from each kidney). Patients with PWV> 12 m/s showed higher values of RI, both in the overall population (p< 0.001) and in the subgroups with (p<0.01) and without CKD (p<0.01). In addition, a statistically significant correlation was observed between aortic PWV and RI in the whole population (r = 0.38, p<0.001) and in the subgroups with (r = 0.35, p<0.001) and without CKD (r = 0:31, p<0.001). These correlations held even after adjustment for several confounding factors. CONCLUSIONS: Showing a strong independent association between renal RI and aortic PWV, seem to corroborate the concept that the RI, beyond its prognostic renal value, may be considered as a marker of systemic vascular changes and therefore a predictor of cardiovascular risk.",
author = "{Mule’, G; Cottone S.} and Giovanni Cerasola and Santina Cottone and Giuseppe Mule' and Calogero Geraci and Manuela Mogavero and Giulio Geraci and Francesco D'Ignoto",
year = "2013",
language = "English",

}

TY - CONF

T1 - RELATIONSHIP BETWEEN AORTIC PULSE WAVE VELOCITY AND RENAL RESISTIVE INDEX IN HYPERTENSIVE PATIENTS.

AU - Mule’, G; Cottone S.

AU - Cerasola, Giovanni

AU - Cottone, Santina

AU - Mule', Giuseppe

AU - Geraci, Calogero

AU - Mogavero, Manuela

AU - Geraci, Giulio

AU - D'Ignoto, Francesco

PY - 2013

Y1 - 2013

N2 - INTRODUCTION: The assessment of renal hemodynamic parameters by duplex Doppler sonography has been used for many years as a diagnostic tool in the daily workup of kidney diseases. Recent data suggest that these parameters, especially the intrarenal resistive index (RI), may be also associated with systemic vascular changes and cardiovascular risk. However, conflicting data exist about the independent association of aortic stiffness with RI. AIM: The aim was to evaluate the relationship between RI and arterial stiffness, assessed by aortic pulse wave velocity (PWV), in the hypertensive subjects consecutively attending our hypertension centre. METHODS: We enrolled 264 subjects, aged between 30 and 70 years. They were divided into two groups, either with normal renal function (n = 140) or with chronic kidney disease (CKD), ranging from stage 1 to stage 4 of the KDIGO classification (n = 124). RESULTS: The aortic PWV was measured by a computerized oscillometric method (Arteriograph). The GFR was estimated byCKD-EPI equation.Asingle operator performed duplex Doppler assessment of the renal arteries. Doppler signals were obtained by placing the sample volume along the course of the interlobar arteries. The RI was calculated as the average of six measurements (three from each kidney). Patients with PWV> 12 m/s showed higher values of RI, both in the overall population (p< 0.001) and in the subgroups with (p<0.01) and without CKD (p<0.01). In addition, a statistically significant correlation was observed between aortic PWV and RI in the whole population (r = 0.38, p<0.001) and in the subgroups with (r = 0.35, p<0.001) and without CKD (r = 0:31, p<0.001). These correlations held even after adjustment for several confounding factors. CONCLUSIONS: Showing a strong independent association between renal RI and aortic PWV, seem to corroborate the concept that the RI, beyond its prognostic renal value, may be considered as a marker of systemic vascular changes and therefore a predictor of cardiovascular risk.

AB - INTRODUCTION: The assessment of renal hemodynamic parameters by duplex Doppler sonography has been used for many years as a diagnostic tool in the daily workup of kidney diseases. Recent data suggest that these parameters, especially the intrarenal resistive index (RI), may be also associated with systemic vascular changes and cardiovascular risk. However, conflicting data exist about the independent association of aortic stiffness with RI. AIM: The aim was to evaluate the relationship between RI and arterial stiffness, assessed by aortic pulse wave velocity (PWV), in the hypertensive subjects consecutively attending our hypertension centre. METHODS: We enrolled 264 subjects, aged between 30 and 70 years. They were divided into two groups, either with normal renal function (n = 140) or with chronic kidney disease (CKD), ranging from stage 1 to stage 4 of the KDIGO classification (n = 124). RESULTS: The aortic PWV was measured by a computerized oscillometric method (Arteriograph). The GFR was estimated byCKD-EPI equation.Asingle operator performed duplex Doppler assessment of the renal arteries. Doppler signals were obtained by placing the sample volume along the course of the interlobar arteries. The RI was calculated as the average of six measurements (three from each kidney). Patients with PWV> 12 m/s showed higher values of RI, both in the overall population (p< 0.001) and in the subgroups with (p<0.01) and without CKD (p<0.01). In addition, a statistically significant correlation was observed between aortic PWV and RI in the whole population (r = 0.38, p<0.001) and in the subgroups with (r = 0.35, p<0.001) and without CKD (r = 0:31, p<0.001). These correlations held even after adjustment for several confounding factors. CONCLUSIONS: Showing a strong independent association between renal RI and aortic PWV, seem to corroborate the concept that the RI, beyond its prognostic renal value, may be considered as a marker of systemic vascular changes and therefore a predictor of cardiovascular risk.

UR - http://hdl.handle.net/10447/84243

M3 - Paper

ER -