Relation of oxidant stress with endothelial activation in hemodialysis.

Francesco Vaccaro, Emilio Nardi, Giovanni Cerasola, Marco Guarneri, Santina Cottone, Giuseppe Mule', Alessandro Palermo, Anna Vadala', Rosalia Arsena

Risultato della ricerca: Otherpeer review


Introduction and Aims: Enhanced oxidative stress may be implicated inthe pathogenesis of atherosclerosis in hemodialysed patients (HDs). Wehypothesized that in hypertensive HDs oxidative stress should be elevatedand associated to endothelial activation, and inflammation.Methods:We examined oxidative stress, as measured by 8-ISO-PGF2alpha,endothelial activation by measuring endothelin-1 (ET-1) and adhesionmolecules ICAM-1 and VCAM-1, and the biomarker of acute-phaseinflammation CRP.In 52 mild HDs and in 50 healthy controls (Cs) we analysed, in theinterdialytic day, plasma levels of 8-ISO-PGF2alpha, ET-1, ICAM-1 andVCAM-1, and high sensitivity CRP.Results: The comparison between Cs and HDs demonstrated in the lattergroup significantly higher levels of 8-ISO-PGF2alpha (p<0.0001), CRP(p<0.001), ET-1 (p< 0.001), and ICAM-1 and VCAM-1 (p<0.001).We divided successively the overall group according to tertiles of 8-ISOPGF2alpha,and we observed increasing levels of adhesion molecules, ET-1,and CRP along with the increasing tertiles, with significant differencesbetween tertiles in each parameter.The multiple regression analysis carried out considering 8-ISO-PGF2alphaas dependent variable in a model including adhesion molecules, ET-1, CRP,systolic and diastolic blood pressure, serum creatinine and glucose, age,sex, and BMI demonstrated a significant relationship of 8-ISO-PGF2alphawith VCAM-1 (Beta 0.56, p = 0.00001), and ET-1 (Beta 0.55, p = 0.0002).Conclusions: In conclusion, our findings show that in long term hypertensiveHDs oxidative stress is increased and related to endothelial activation, inthe presence of augmented index of acute inflammation.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2006


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