Background: C-reactive protein (CRP) predicts cardiovascularoutcome. Oxidative stress is considered to beinvolved in endothelial alteration. We hypothesized that inessential hypertension (EH), oxidative stress, as measured by8-iso-prostaglandin-F2 alfa (8-iso-PGF2alfa), should be associatedwith increased CRP and endothelial activation, as evaluatedby soluble intercellular adhesion molecule–1 (ICAM-1) andvascular adhesion molecule–1 (VCAM-1) plasma levels.Methods: In 83 subjects with mild EH and in 50healthy control subjects we measured, in basal conditions,plasma levels of hs-CRP, 8-iso-PGF2 alfa, ICAM-1 andVCAM-1, and tumor necrosis factor–alfa (TNF-alfa).Results: Subjects with EH had higher levels of 8-iso-PGF2 alfa(P < .0001), CRP (P < .001), ICAM-1 andVCAM-1 (P <.001), and TNF- (P < .001) than didcontrol subjects. We divided successively EH according toCRP values (1, 1–3, 3 mg/L), and we observed increasingand significantly different levels of the endothelialparameters and of TNF- along with increasing CRP.Linear analysis of correlation pointed out significant correlationof CRP with 8-iso-PGF2 alfa (r = 0.730, P < .001),ICAM-1 and VCAM-1 (r =0.642 and 0.468, P < .001respectively), and TNF- alfa (r =0.609, P< .001).Multiple regression analysis using CRP as a dependentvariable confirmed the relationship of CRP with systolicblood pressure ( beta = 0.216, P = .039) and with 8-iso-PGF2alfa(beta 0.602, P = .0001).Conclusions: Our data demonstrate that in EH, inflammatorymolecules such as CRP and TNF-alfa are increasedand related to both oxidative stress and endothelialactivation.
|Numero di pagine||6|
|Rivista||American Journal of Hypertension|
|Stato di pubblicazione||Published - 2006|
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