Abstract

Background: C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F2 alfa (8-iso-PGF2alfa), should be associated with increased CRP and endothelial activation, as evaluated by soluble intercellular adhesion molecule–1 (ICAM-1) and vascular adhesion molecule–1 (VCAM-1) plasma levels. Methods: In 83 subjects with mild EH and in 50 healthy control subjects we measured, in basal conditions, plasma levels of hs-CRP, 8-iso-PGF2 alfa, ICAM-1 and VCAM-1, and tumor necrosis factor–alfa (TNF-alfa). Results: Subjects with EH had higher levels of 8-iso- PGF2 alfa(P < .0001), CRP (P < .001), ICAM-1 and VCAM-1 (P <.001), and TNF- (P < .001) than did control subjects. We divided successively EH according to CRP values (1, 1–3, 3 mg/L), and we observed increasing and significantly different levels of the endothelial parameters and of TNF- along with increasing CRP. Linear analysis of correlation pointed out significant correlation of CRP with 8-iso-PGF2 alfa (r = 0.730, P < .001), ICAM-1 and VCAM-1 (r =0.642 and 0.468, P < .001 respectively), and TNF- alfa (r =0.609, P< .001). Multiple regression analysis using CRP as a dependent variable confirmed the relationship of CRP with systolic blood pressure ( beta = 0.216, P = .039) and with 8-iso-PGF2alfa (beta 0.602, P = .0001). Conclusions: Our data demonstrate that in EH, inflammatory molecules such as CRP and TNF-alfa are increased and related to both oxidative stress and endothelial activation.
Lingua originaleEnglish
pagine (da-a)313-318
Numero di pagine6
RivistaAmerican Journal of Hypertension
Volume19
Stato di pubblicazionePublished - 2006

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C-Reactive Protein
Oxidative Stress
8-epi-prostaglandin F2alpha
Dinoprost
Intercellular Adhesion Molecule-1
Vascular Cell Adhesion Molecule-1
Tumor Necrosis Factor-alpha
Essential Hypertension
Regression Analysis
Hypertension
Pressure

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cita questo

@article{1028fcec65fa4b11b6f9a4b5146a7155,
title = "Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.",
abstract = "Background: C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F2 alfa (8-iso-PGF2alfa), should be associated with increased CRP and endothelial activation, as evaluated by soluble intercellular adhesion molecule–1 (ICAM-1) and vascular adhesion molecule–1 (VCAM-1) plasma levels. Methods: In 83 subjects with mild EH and in 50 healthy control subjects we measured, in basal conditions, plasma levels of hs-CRP, 8-iso-PGF2 alfa, ICAM-1 and VCAM-1, and tumor necrosis factor–alfa (TNF-alfa). Results: Subjects with EH had higher levels of 8-iso- PGF2 alfa(P < .0001), CRP (P < .001), ICAM-1 and VCAM-1 (P <.001), and TNF- (P < .001) than did control subjects. We divided successively EH according to CRP values (1, 1–3, 3 mg/L), and we observed increasing and significantly different levels of the endothelial parameters and of TNF- along with increasing CRP. Linear analysis of correlation pointed out significant correlation of CRP with 8-iso-PGF2 alfa (r = 0.730, P < .001), ICAM-1 and VCAM-1 (r =0.642 and 0.468, P < .001 respectively), and TNF- alfa (r =0.609, P< .001). Multiple regression analysis using CRP as a dependent variable confirmed the relationship of CRP with systolic blood pressure ( beta = 0.216, P = .039) and with 8-iso-PGF2alfa (beta 0.602, P = .0001). Conclusions: Our data demonstrate that in EH, inflammatory molecules such as CRP and TNF-alfa are increased and related to both oxidative stress and endothelial activation.",
author = "Giovanni Cerasola and Anna Vadala' and Santina Cottone and Giuseppe Mule' and Emilio Nardi and Chiara Briolotta and Rosalia Arsena and Marco Guarneri and Alessandro Palermo and Raffaella Riccobene and Santina Cottone",
year = "2006",
language = "English",
volume = "19",
pages = "313--318",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",

}

TY - JOUR

T1 - Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.

AU - Cerasola, Giovanni

AU - Vadala', Anna

AU - Cottone, Santina

AU - Mule', Giuseppe

AU - Nardi, Emilio

AU - Briolotta, Chiara

AU - Arsena, Rosalia

AU - Guarneri, Marco

AU - Palermo, Alessandro

AU - Riccobene, Raffaella

AU - Cottone, Santina

PY - 2006

Y1 - 2006

N2 - Background: C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F2 alfa (8-iso-PGF2alfa), should be associated with increased CRP and endothelial activation, as evaluated by soluble intercellular adhesion molecule–1 (ICAM-1) and vascular adhesion molecule–1 (VCAM-1) plasma levels. Methods: In 83 subjects with mild EH and in 50 healthy control subjects we measured, in basal conditions, plasma levels of hs-CRP, 8-iso-PGF2 alfa, ICAM-1 and VCAM-1, and tumor necrosis factor–alfa (TNF-alfa). Results: Subjects with EH had higher levels of 8-iso- PGF2 alfa(P < .0001), CRP (P < .001), ICAM-1 and VCAM-1 (P <.001), and TNF- (P < .001) than did control subjects. We divided successively EH according to CRP values (1, 1–3, 3 mg/L), and we observed increasing and significantly different levels of the endothelial parameters and of TNF- along with increasing CRP. Linear analysis of correlation pointed out significant correlation of CRP with 8-iso-PGF2 alfa (r = 0.730, P < .001), ICAM-1 and VCAM-1 (r =0.642 and 0.468, P < .001 respectively), and TNF- alfa (r =0.609, P< .001). Multiple regression analysis using CRP as a dependent variable confirmed the relationship of CRP with systolic blood pressure ( beta = 0.216, P = .039) and with 8-iso-PGF2alfa (beta 0.602, P = .0001). Conclusions: Our data demonstrate that in EH, inflammatory molecules such as CRP and TNF-alfa are increased and related to both oxidative stress and endothelial activation.

AB - Background: C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F2 alfa (8-iso-PGF2alfa), should be associated with increased CRP and endothelial activation, as evaluated by soluble intercellular adhesion molecule–1 (ICAM-1) and vascular adhesion molecule–1 (VCAM-1) plasma levels. Methods: In 83 subjects with mild EH and in 50 healthy control subjects we measured, in basal conditions, plasma levels of hs-CRP, 8-iso-PGF2 alfa, ICAM-1 and VCAM-1, and tumor necrosis factor–alfa (TNF-alfa). Results: Subjects with EH had higher levels of 8-iso- PGF2 alfa(P < .0001), CRP (P < .001), ICAM-1 and VCAM-1 (P <.001), and TNF- (P < .001) than did control subjects. We divided successively EH according to CRP values (1, 1–3, 3 mg/L), and we observed increasing and significantly different levels of the endothelial parameters and of TNF- along with increasing CRP. Linear analysis of correlation pointed out significant correlation of CRP with 8-iso-PGF2 alfa (r = 0.730, P < .001), ICAM-1 and VCAM-1 (r =0.642 and 0.468, P < .001 respectively), and TNF- alfa (r =0.609, P< .001). Multiple regression analysis using CRP as a dependent variable confirmed the relationship of CRP with systolic blood pressure ( beta = 0.216, P = .039) and with 8-iso-PGF2alfa (beta 0.602, P = .0001). Conclusions: Our data demonstrate that in EH, inflammatory molecules such as CRP and TNF-alfa are increased and related to both oxidative stress and endothelial activation.

UR - http://hdl.handle.net/10447/37418

UR - http://ajh.oxfordjournals.org/content/19/3/313.long

M3 - Article

VL - 19

SP - 313

EP - 318

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

ER -