Relation between structural and release properties in a polysaccharide gel system

Vincenza Martorana, Gennara Cavallaro, Marco Mangione, Giacomazza, Maria Rosalia Mangione, Martorana, Bulone, Pier Luigi San Biagio

Risultato della ricerca: Article

10 Citazioni (Scopus)

Abstract

The potential utility of κ-carrageenan gels for preparing drug release devices is here shown. Structural properties of κ-carrageenan gels prepared with different salt composition and containing Ketoprofen sodium salt, as model drug, have been evaluated with static light scattering and rheological measurements. These properties have been correlated with release profiles in vitro at pH 5.5. Release properties from gelled matrices have been compared with those obtained by two commercial products containing the same drug. Results show that: i) in this system it is possible to easily control the gel texture by using different cationic concentration; ii) the kinetics of drug release by κ-carrageenan gels are dependent on the structural properties of matrices; iii) in the typical interval time used in classical local applications, all gel samples release the loaded drug almost completely, at difference with the commercial products. All these findings can provide useful suggestions for the realization of classical topical release systems.
Lingua originaleEnglish
pagine (da-a)18-22
Numero di pagine5
RivistaBiophysical Chemistry
Volume129
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Organic Chemistry
  • Biochemistry

Cita questo

Relation between structural and release properties in a polysaccharide gel system. / Martorana, Vincenza; Cavallaro, Gennara; Mangione, Marco; Giacomazza; Mangione, Maria Rosalia; Martorana; Bulone; San Biagio, Pier Luigi.

In: Biophysical Chemistry, Vol. 129, 2007, pag. 18-22.

Risultato della ricerca: Article

Martorana, V, Cavallaro, G, Mangione, M, Giacomazza, Mangione, MR, Martorana, Bulone & San Biagio, PL 2007, 'Relation between structural and release properties in a polysaccharide gel system', Biophysical Chemistry, vol. 129, pagg. 18-22.
Martorana, Vincenza ; Cavallaro, Gennara ; Mangione, Marco ; Giacomazza ; Mangione, Maria Rosalia ; Martorana ; Bulone ; San Biagio, Pier Luigi. / Relation between structural and release properties in a polysaccharide gel system. In: Biophysical Chemistry. 2007 ; Vol. 129. pagg. 18-22.
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AU - Martorana, Vincenza

AU - Cavallaro, Gennara

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AU - Mangione, Maria Rosalia

AU - Martorana, null

AU - Bulone, null

AU - San Biagio, Pier Luigi

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AB - The potential utility of κ-carrageenan gels for preparing drug release devices is here shown. Structural properties of κ-carrageenan gels prepared with different salt composition and containing Ketoprofen sodium salt, as model drug, have been evaluated with static light scattering and rheological measurements. These properties have been correlated with release profiles in vitro at pH 5.5. Release properties from gelled matrices have been compared with those obtained by two commercial products containing the same drug. Results show that: i) in this system it is possible to easily control the gel texture by using different cationic concentration; ii) the kinetics of drug release by κ-carrageenan gels are dependent on the structural properties of matrices; iii) in the typical interval time used in classical local applications, all gel samples release the loaded drug almost completely, at difference with the commercial products. All these findings can provide useful suggestions for the realization of classical topical release systems.

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