Regulation of ISWI chromatin remodelling activity

Risultato della ricerca: Article

15 Citazioni (Scopus)

Abstract

The packaging of the eukaryotic genome into chromatin facilitates the storage of the genetic information within the nucleus, but prevents the access to the underlying DNA sequences. Structural changes in chromatin are mediated by several mechanisms. Among them, ATP-dependent remodelling complexes belonging to ISWI family provides one of the best examples that eukaryotic cells evolved to finely regulate these changes. ISWI-containing complexes use the energy derived from ATP hydrolysis to rearrange nucleosomes on chromatin in order to favour specific nuclear reactions. The combination of regulatory nuclear factors associated with the ATPase subunit as well as its modulation by specific histone modifications, specializes the nuclear function of each ISWI-containing complex. Here we review the different ways by which ISWI enzymatic activity can be modulated and regulated in the nucleus of eukaryotic cells.
Lingua originaleEnglish
Numero di pagine11
RivistaChromosoma
Volume123
Stato di pubblicazionePublished - 2014

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Chromatin Assembly and Disassembly
Chromatin
Eukaryotic Cells
Histone Code
Adenosine Triphosphate
Nucleosomes
Information Storage and Retrieval
Product Packaging
Adenosine Triphosphatases
Hydrolysis
Genome

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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Regulation of ISWI chromatin remodelling activity. / Corona, Davide.

In: Chromosoma, Vol. 123, 2014.

Risultato della ricerca: Article

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AB - The packaging of the eukaryotic genome into chromatin facilitates the storage of the genetic information within the nucleus, but prevents the access to the underlying DNA sequences. Structural changes in chromatin are mediated by several mechanisms. Among them, ATP-dependent remodelling complexes belonging to ISWI family provides one of the best examples that eukaryotic cells evolved to finely regulate these changes. ISWI-containing complexes use the energy derived from ATP hydrolysis to rearrange nucleosomes on chromatin in order to favour specific nuclear reactions. The combination of regulatory nuclear factors associated with the ATPase subunit as well as its modulation by specific histone modifications, specializes the nuclear function of each ISWI-containing complex. Here we review the different ways by which ISWI enzymatic activity can be modulated and regulated in the nucleus of eukaryotic cells.

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