Recovery of damaged skeletal muscle in mdx mice through low-intensity endurance exercise

Natale Belluardo, Giuseppe Morici, Giuseppa Mudo', Coco, Vincenzo Perciavalle, Monica Frinchi

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20 Citazioni (Scopus)


The lack of dystrophin in mdx mice leads to cycles of muscle degeneration and regeneration processes. Various strategies have been proposed inorder to reduce the muscle-wasting component of muscular dystrophy, including implementation of an exercise programme. The aim of this study was to examine how low-intensity enduranceexercise affects the degeneration-regeneration process in dystrophic muscle of male mdx mice. Mice were subjected to low-intensity endurance exercise by running on a motorizedRota-Rod for 5 days/week for 6 weeks. Histomorphological analysis showed a signifi cant reduction of measured inflammatory-necrotic areas in both gastrocnemius and quadriceps muscleof exercised mdx mice as compared to matched sedentary mdx mice. The degenerative-regenerative process was also evaluated by examining the protein levels of connexin 39 (Cx39), a specifi c gene expressed in injured muscles.Cx39 was not detected in sedentary wild type mice, whereas it was found markedly increased in sedentary mdx mice, revealing active muscledegeneration-regeneration process. These Cx39 protein levels were signifi cantly reduced in muscles of mdx mice exercised for 30 and 40 days, revealing together with histomorphological analysis a strong reduction of degeneration process in mice subjected to low-intensity endurance exercise. Muscles of exercised mdx mice did notshow significant changes in force and fatigue resistance as compared to sedentary mdx mice.Overall in this study we found that specifi c lowintensity endurance exercise induces a beneficial effect probably by reducing the degeneration ofdystrophic muscle.
Lingua originaleEnglish
pagine (da-a)19-27
Numero di pagine9
RivistaInternational Journal of Sports Medicine
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3600.3612???


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