Recovery of damaged skeletal muscle in mdx mice through low-intensity endurance exercise

Natale Belluardo, Giuseppe Morici, Giuseppa Mudo', Coco, Vincenzo Perciavalle, Monica Frinchi

Risultato della ricerca: Articlepeer review

20 Citazioni (Scopus)

Abstract

The lack of dystrophin in mdx mice leads to cycles of muscle degeneration and regeneration processes. Various strategies have been proposed inorder to reduce the muscle-wasting component of muscular dystrophy, including implementation of an exercise programme. The aim of this study was to examine how low-intensity enduranceexercise affects the degeneration-regeneration process in dystrophic muscle of male mdx mice. Mice were subjected to low-intensity endurance exercise by running on a motorizedRota-Rod for 5 days/week for 6 weeks. Histomorphological analysis showed a signifi cant reduction of measured inflammatory-necrotic areas in both gastrocnemius and quadriceps muscleof exercised mdx mice as compared to matched sedentary mdx mice. The degenerative-regenerative process was also evaluated by examining the protein levels of connexin 39 (Cx39), a specifi c gene expressed in injured muscles.Cx39 was not detected in sedentary wild type mice, whereas it was found markedly increased in sedentary mdx mice, revealing active muscledegeneration-regeneration process. These Cx39 protein levels were signifi cantly reduced in muscles of mdx mice exercised for 30 and 40 days, revealing together with histomorphological analysis a strong reduction of degeneration process in mice subjected to low-intensity endurance exercise. Muscles of exercised mdx mice did notshow significant changes in force and fatigue resistance as compared to sedentary mdx mice.Overall in this study we found that specifi c lowintensity endurance exercise induces a beneficial effect probably by reducing the degeneration ofdystrophic muscle.
Lingua originaleEnglish
pagine (da-a)19-27
Numero di pagine9
RivistaInternational Journal of Sports Medicine
Volume35
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3600.3612???

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